(1R,2S)-1-(4-methoxy-phenyl)-2-((4R,5R)-3-methyl-4-nitro-4,5-dihydro-isoxazol-5-yl)-ethane-1,2-diol

Base Information

• Chemical Name: (1R,2S)-1-(4-methoxy-phenyl)-2-((4R,5R)-3-methyl-4-nitro-4,5-dihydro-isoxazol-5-yl)-ethane-1,2-diol
• CAS No.: 1021951-98-3
• Molecular Formula: C₁₃H₁₆N₂O₆
• Molecular Weight: 296.28

Synonyms:(1R,2S)-1-(4-methoxy-phenyl)-2-((4R,5R)-3-methyl-4-nitro-4,5-dihydro-isoxazol-5-yl)-ethane-1,2-diol

Chemical Property of (1R,2S)-1-(4-methoxy-phenyl)-2-((4R,5R)-3-methyl-4-nitro-4,5-dihydro-isoxazol-5-yl)-ethane-1,2-diol

Chemical Property:

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Technology Process of (1R,2S)-1-(4-methoxy-phenyl)-2-((4R,5R)-3-methyl-4-nitro-4,5-dihydro-isoxazol-5-yl)-ethane-1,2-diol

There total 1 articles about (1R,2S)-1-(4-methoxy-phenyl)-2-((4R,5R)-3-methyl-4-nitro-4,5-dihydro-isoxazol-5-yl)-ethane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(1R,2S)-1-(4-methoxyphenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane-1,2-diol (1021951-87-0) → (1R,2S)-1-(4-methoxy-phenyl)-2-((4S,5S)-3-methyl-4-nitro-4,5-dihydro-isoxazol-5-yl)-ethane-1,2-diol (1021952-08-8) + (1R,2S)-1-(4-methoxy-phenyl)-2-((4R,5R)-3-methyl-4-nitro-4,5-dihydro-isoxazol-5-yl)-ethane-1,2-diol (1021951-98-3)

Guidance literature:

(1R,2S)-1-(4-methoxyphenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane-1,2-diol; With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 ℃; for 0.833333h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 0 - 5 ℃; for 1h; pH=2.0;

DOI:10.1021/ol800397z

Reference yield: 96.0%

(1R,2S)-1-(4-methoxy-phenyl)-2-((4R,5R)-3-methyl-4-nitro-4,5-dihydro-isoxazol-5-yl)-ethane-1,2-diol (1021951-98-3) + acetone (67-64-1) → (4R,5R)-5-[(4S,5R)-5-(4-Methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methyl-4-nitro-4,5-dihydroisoxazole (1021952-18-0)

Guidance literature:

With toluene-4-sulfonic acid;

DOI:10.1021/ol800397z

Reference yield: 70.0%

(1R,2S)-1-(4-methoxy-phenyl)-2-((4R,5R)-3-methyl-4-nitro-4,5-dihydro-isoxazol-5-yl)-ethane-1,2-diol (1021951-98-3) → (1R,2S,3R,4R)-4-amino-1-(4-methoxy-phenyl)-5-imino-hexane-1,2,3-triol (1021952-16-8)

Guidance literature:

With acetic acid; zinc; In water; at 60 ℃; for 6h;

DOI:10.1021/ol800397z

upstream raw materials:

(1R,2S)-1-(4-methoxyphenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane-1,2-diol

Downstream raw materials:

(1R,2S,3R,4R)-4-amino-1-(4-methoxy-phenyl)-5-imino-hexane-1,2,3-triol

(4R,5R)-5-[(4S,5R)-5-(4-Methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methyl-4-nitro-4,5-dihydroisoxazole

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