5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridin-5-yl)pentanoic acid

Base Information

Chemical Name:5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridin-5-yl)pentanoic acid
CAS No.:1345174-43-7
Molecular Formula:C₂₂H₂₄FN₃O₆S
Molecular Weight:477.513
Hs Code.:

Synonyms:5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridin-5-yl)pentanoic acid

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Chemical Property of 5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridin-5-yl)pentanoic acid

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Technology Process of 5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridin-5-yl)pentanoic acid

There total 7 articles about 5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridin-5-yl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345174-41-5
ethyl 5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridin-5-yl)pentanoate

: 1345174-43-7
5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridin-5-yl)pentanoic acid

Guidance literature:: With water; lithium hydroxide; In methanol; for 1h; Reflux;

Reference yield:

: 5154-00-7,59315-47-8
6-amino-pyridin-2-ol

: 1345174-43-7
5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridin-5-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-iodo-succinimide; acetic acid / 1 h

2.1: 1 h / 110 °C

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 - 20 °C / Inert atmosphere

3.2: 7 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 16 h / 0 - 5 °C

4.2: 0 °C

5.1: potassium carbonate / acetone / 24 h / 60 °C

6.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 1 h / 20 °C

6.2: 0.5 h / 20 °C

6.3: 0.33 h / 120 °C / Inert atmosphere

7.1: water; lithium hydroxide / methanol / 1 h / Reflux

With N-iodo-succinimide; water; potassium carbonate; acetic acid; triethylamine; 9-bora-bicyclo[3.3.1]nonane; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; acetone;

Reference yield:

: 1345173-96-7
acetic acid 6-diacetylamino-3,5-diiodo-pyridin-2-yl ester

: 1345174-43-7
5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridin-5-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 - 20 °C / Inert atmosphere

1.2: 7 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 16 h / 0 - 5 °C

2.2: 0 °C

3.1: potassium carbonate / acetone / 24 h / 60 °C

4.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 1 h / 20 °C

4.2: 0.5 h / 20 °C

4.3: 0.33 h / 120 °C / Inert atmosphere

5.1: water; lithium hydroxide / methanol / 1 h / Reflux

With water; potassium carbonate; triethylamine; 9-bora-bicyclo[3.3.1]nonane; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; acetone;