6-amino-2-(4-fluoro-phenyl)-5-iodo-furo[2,3-b]pyridine-3-carboxylic acid

Base Information

Chemical Name:6-amino-2-(4-fluoro-phenyl)-5-iodo-furo[2,3-b]pyridine-3-carboxylic acid
CAS No.:1345173-98-9
Molecular Formula:C₁₄H₈FIN₂O₃
Molecular Weight:398.132
Hs Code.:

Synonyms:6-amino-2-(4-fluoro-phenyl)-5-iodo-furo[2,3-b]pyridine-3-carboxylic acid

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Chemical Property of 6-amino-2-(4-fluoro-phenyl)-5-iodo-furo[2,3-b]pyridine-3-carboxylic acid

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Technology Process of 6-amino-2-(4-fluoro-phenyl)-5-iodo-furo[2,3-b]pyridine-3-carboxylic acid

There total 3 articles about 6-amino-2-(4-fluoro-phenyl)-5-iodo-furo[2,3-b]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 766-98-3
1-ethynyl-4-fluorobenzene

: 201230-82-2
carbon monoxide

: 1345173-96-7
acetic acid 6-diacetylamino-3,5-diiodo-pyridin-2-yl ester

: 1345173-98-9
6-amino-2-(4-fluoro-phenyl)-5-iodo-furo[2,3-b]pyridine-3-carboxylic acid

Guidance literature:: 1-ethynyl-4-fluorobenzene; acetic acid 6-diacetylamino-3,5-diiodo-pyridin-2-yl ester; With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 2 - 20 ℃; Inert atmosphere;

carbon monoxide; With sodium acetate; copper dichloride; In tetrahydrofuran; methanol; at 20 ℃; for 7h;

Reference yield:

: 5154-00-7,59315-47-8
6-amino-pyridin-2-ol

: 1345173-98-9
6-amino-2-(4-fluoro-phenyl)-5-iodo-furo[2,3-b]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-iodo-succinimide; acetic acid / 1 h

2.1: 1 h / 110 °C

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 - 20 °C / Inert atmosphere

3.2: 7 h / 20 °C

With N-iodo-succinimide; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran;

Reference yield:

: 6-amino-3,5-diiodo-pyridin-2-ol

: 1345173-98-9
6-amino-2-(4-fluoro-phenyl)-5-iodo-furo[2,3-b]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1 h / 110 °C

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 - 20 °C / Inert atmosphere

2.2: 7 h / 20 °C

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran;