2-(4-fluorophenyl)-6,8-bis(4-methoxyphenyl)-4-(phenylethynyl)quinazoline

Base Information

Chemical Name:2-(4-fluorophenyl)-6,8-bis(4-methoxyphenyl)-4-(phenylethynyl)quinazoline
CAS No.:1625647-33-7
Molecular Formula:C₃₆H₂₅FN₂O₂
Molecular Weight:536.605
Hs Code.:

Synonyms:2-(4-fluorophenyl)-6,8-bis(4-methoxyphenyl)-4-(phenylethynyl)quinazoline

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Chemical Property of 2-(4-fluorophenyl)-6,8-bis(4-methoxyphenyl)-4-(phenylethynyl)quinazoline

Chemical Property:

Purity/Quality:

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Technology Process of 2-(4-fluorophenyl)-6,8-bis(4-methoxyphenyl)-4-(phenylethynyl)quinazoline

There total 5 articles about 2-(4-fluorophenyl)-6,8-bis(4-methoxyphenyl)-4-(phenylethynyl)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1625647-17-7
6,8-dibromo-2-(4-fluorophenyl)-4-(phenylethynyl)quinazoline

: 5720-07-0
4-methoxyphenylboronic acid

: 1625647-33-7
2-(4-fluorophenyl)-6,8-bis(4-methoxyphenyl)-4-(phenylethynyl)quinazoline

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; water; at 100 ℃; for 5.5h; Inert atmosphere;
DOI:10.3390/molecules19010795

Reference yield:

: 6,8-dibromo-4-chloro-2-(4-fluorophenyl)quinazoline

: 1625647-33-7
2-(4-fluorophenyl)-6,8-bis(4-methoxyphenyl)-4-(phenylethynyl)quinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; caesium carbonate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; tricyclohexylphosphine / 1,4-dioxane; water / 5.5 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; caesium carbonate; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; water; 1: |Sonogashira Cross-Coupling / 2: |Suzuki-Miyaura Coupling;
DOI:10.3390/molecules19010795

Reference yield:

: 16524-04-2
2‐amino‐3,5‐dibromobenzamide

: 1625647-33-7
2-(4-fluorophenyl)-6,8-bis(4-methoxyphenyl)-4-(phenylethynyl)quinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: iodine / ethanol / 7 h / Reflux

2: thionyl chloride; N,N-dimethyl-formamide / 2 h / 20 °C / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; caesium carbonate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

4: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; tricyclohexylphosphine / 1,4-dioxane; water / 5.5 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; iodine; potassium carbonate; caesium carbonate; N,N-dimethyl-formamide; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; water; 3: |Sonogashira Cross-Coupling / 4: |Suzuki-Miyaura Coupling;
DOI:10.3390/molecules19010795