2-AMINO-5-CHLORO-3-(TRIMETHYLSILYL)ACETYLENYLPYRIDINE

Base Information

• Chemical Name: 2-AMINO-5-CHLORO-3-(TRIMETHYLSILYL)ACETYLENYLPYRIDINE
• CAS No.: 866318-90-3
• Molecular Formula: C10H13 Cl N2 Si
• Molecular Weight: 224.765
• Hs Code.: 2933399090
• Mol file: 866318-90-3.mol

Synonyms:2-Pyridinamine,5-chloro-3-[(trimethylsilyl)ethynyl]- (9CI);[5-Chloro-3-[(trimethylsilanyl)ethynyl]pyridin-2-yl]amine

Chemical Property of 2-AMINO-5-CHLORO-3-(TRIMETHYLSILYL)ACETYLENYLPYRIDINE

Chemical Property:

• PSA: 38.91000
• LogP: 3.12730
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-chloro-3-[2-(trimethylsilyl)ethynyl]-2-pyridinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-CHLORO-3-(TRIMETHYLSILYL)ACETYLENYLPYRIDINE

There total 1 articles about 2-AMINO-5-CHLORO-3-(TRIMETHYLSILYL)ACETYLENYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-amino-3-bromo-5-chloropyridine (26163-03-1) + trimethylsilylacetylene (1066-54-2) → 2-amino-5-chloro-3-[(trimethylsilyl)ethynyl]pyridine (866318-90-3)

Guidance literature:

With copper(l) iodide; triethylamine; In tetrahydrofuran; at -5 - 5 ℃; Inert atmosphere;

Reference yield: 85.0%

2-amino-5-chloro-3-[(trimethylsilyl)ethynyl]pyridine (866318-90-3) → 5-chloro-1H-pyrrolo[2,3-b]pyridine (866546-07-8)

Guidance literature:

With potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 1h; Inert atmosphere;

Reference yield: 82.0%

2-amino-5-chloro-3-[(trimethylsilyl)ethynyl]pyridine (866318-90-3) + N-(3,5-dimethoxyphenyl)-3-iodo-4-methylbenzamide → 3-((2-amino-5-chloropyridin-3-yl)ethynyl)-N-(3,5-dimethoxyphenyl)-4-methylbenzamide

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; cesium fluoride; In acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.9b01912

upstream raw materials:

2-amino-3-bromo-5-chloropyridine

trimethylsilylacetylene

Downstream raw materials:

5-chloro-1H-pyrrolo[2,3-b]pyridine

3-bromo-5-chloro-1 H-pyrrolo[2,3-b]pyridine

3-bromo-5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridine

5-chloro-1-(p-tolylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-b]pyridine

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