11-<1-methylene-4-(bromomethylene)phenylene>-1,4,7-tris(p-tolylsulfonyl)-1,4,7,11-tetraazacyclotetradecane

Base Information

Chemical Name:11-<1-methylene-4-(bromomethylene)phenylene>-1,4,7-tris(p-tolylsulfonyl)-1,4,7,11-tetraazacyclotetradecane
CAS No.:166303-18-0
Molecular Formula:C₃₉H₄₉BrN₄O₆S₃
Molecular Weight:845.943
Hs Code.:

Synonyms:11-<1-methylene-4-(bromomethylene)phenylene>-1,4,7-tris(p-tolylsulfonyl)-1,4,7,11-tetraazacyclotetradecane

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Chemical Property of 11-<1-methylene-4-(bromomethylene)phenylene>-1,4,7-tris(p-tolylsulfonyl)-1,4,7,11-tetraazacyclotetradecane

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Technology Process of 11-<1-methylene-4-(bromomethylene)phenylene>-1,4,7-tris(p-tolylsulfonyl)-1,4,7,11-tetraazacyclotetradecane

There total 4 articles about 11-<1-methylene-4-(bromomethylene)phenylene>-1,4,7-tris(p-tolylsulfonyl)-1,4,7,11-tetraazacyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 623-24-5
1,4-bis(bromomethyl)benzene

: 66977-70-6
1,4,7-tritosyl-1,4,7,11-tetraazacyclotetradecane

: 166303-18-0
11-<1-methylene-4-(bromomethylene)phenylene>-1,4,7-tris(p-tolylsulfonyl)-1,4,7,11-tetraazacyclotetradecane

Guidance literature:: With potassium carbonate; In acetonitrile; at 50 ℃; for 1h;
DOI:10.1021/jm00002a019

Reference yield:

: 66977-69-3
11-benzyl-1,4,7-tris-(toluene-4-sulfonyl)-1,4,7,11-tetraaza-cyclotetradecane

: 166303-18-0
11-<1-methylene-4-(bromomethylene)phenylene>-1,4,7-tris(p-tolylsulfonyl)-1,4,7,11-tetraazacyclotetradecane

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid / Pd(OH)2/C / Heating

2: 53 percent / K₂CO₃ / acetonitrile / 1 h / 50 °C

With formic acid; potassium carbonate; palladium dihydroxide; In acetonitrile;
DOI:10.1021/jm00002a019

Reference yield:

: 16695-22-0
N,N-bis(tosyloxyethyl)-p-toluenesulfonamide

: 166303-18-0
11-<1-methylene-4-(bromomethylene)phenylene>-1,4,7-tris(p-tolylsulfonyl)-1,4,7,11-tetraazacyclotetradecane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 60 deg C, 2.) DMF, 100-110 deg C

2: formic acid / Pd(OH)2/C / Heating

3: 53 percent / K₂CO₃ / acetonitrile / 1 h / 50 °C

With formic acid; sodium hydride; potassium carbonate; palladium dihydroxide; In acetonitrile;
DOI:10.1021/jm00002a019