(3aR,5aR,10bR)-6-Benzyl-3a-ethyl-1,2,3,3a,4,5,5a,6,11,12-decahydro-6-aza-12a-azonia-indeno[7,1-cd]fluorene; chloride

Base Information

• Chemical Name: (3aR,5aR,10bR)-6-Benzyl-3a-ethyl-1,2,3,3a,4,5,5a,6,11,12-decahydro-6-aza-12a-azonia-indeno[7,1-cd]fluorene; chloride
• CAS No.: 143504-56-7
• Molecular Formula: C₂₆H₃₁N₂*Cl
• Molecular Weight: 406.999
• Mol file: 143504-56-7.mol

Synonyms:(3aR,5aR,10bR)-6-Benzyl-3a-ethyl-1,2,3,3a,4,5,5a,6,11,12-decahydro-6-aza-12a-azonia-indeno[7,1-cd]fluorene; chloride

Chemical Property of (3aR,5aR,10bR)-6-Benzyl-3a-ethyl-1,2,3,3a,4,5,5a,6,11,12-decahydro-6-aza-12a-azonia-indeno[7,1-cd]fluorene; chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aR,5aR,10bR)-6-Benzyl-3a-ethyl-1,2,3,3a,4,5,5a,6,11,12-decahydro-6-aza-12a-azonia-indeno[7,1-cd]fluorene; chloride

There total 1 articles about (3aR,5aR,10bR)-6-Benzyl-3a-ethyl-1,2,3,3a,4,5,5a,6,11,12-decahydro-6-aza-12a-azonia-indeno[7,1-cd]fluorene; chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-3-Ethyl-3-chloropropyl-4a-(nitroethyl)-9-benzylhexahydrocarbazol-4-one (143466-45-9,143466-48-2) → (4R,6aR,11bR)-7-Benzyl-4-(3-chloro-propyl)-4-ethyl-2,4,5,6,6a,7-hexahydro-1H-pyrrolo[2,3-d]carbazole (143466-46-0) + (3aR,5aR,10bR)-6-Benzyl-3a-ethyl-1,2,3,3a,4,5,5a,6,11,12-decahydro-6-aza-12a-azonia-indeno[7,1-cd]fluorene; chloride (143504-56-7)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; at 65 ℃; for 15h; Yield given. Yields of byproduct given;

DOI:10.1016/0040-4039(92)88084-I

Reference yield: 70.0%

(3aR,5aR,10bR)-6-Benzyl-3a-ethyl-1,2,3,3a,4,5,5a,6,11,12-decahydro-6-aza-12a-azonia-indeno[7,1-cd]fluorene; chloride (143504-56-7) → (+/-)-N-Benzyl aspidospermidine (143466-47-1)

Guidance literature:

With hydrogen; Pt/Al₂O₃; In ethanol; for 48h; under 2280 Torr; Ambient temperature;

DOI:10.1016/0040-4039(92)88084-I

upstream raw materials:

cis-3-Ethyl-3-chloropropyl-4a-(nitroethyl)-9-benzylhexahydrocarbazol-4-one

Downstream raw materials:

(+/-)-N-Benzyl aspidospermidine