Technology Process of 20β-benzyloxy-3α-(tetrahydropyran-2-yloxy)-5β-pregnano-18,11β-lactone
There total 7 articles about 20β-benzyloxy-3α-(tetrahydropyran-2-yloxy)-5β-pregnano-18,11β-lactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium amide;
In
toluene;
1.) room temperature, 10 min, 2.) reflux, 20 h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: toluene-p-sulphonic acid monohydrate / tetrahydrofuran / 1.5 h / Ambient temperature
2: 75 percent / zinc borohydride / 1,2-dimethoxy-ethane / 1.5 h / Heating
3: 38 percent / sodamide / toluene / 1.) room temperature, 10 min, 2.) reflux, 20 h
With
zinc borohydride; toluene-4-sulfonic acid; sodium amide;
In
tetrahydrofuran; 1,2-dimethoxyethane; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: NaBH4 / methanol; H2O / 1.5 h / 0 °C
2: 1.) lead tetra-acetate, iodine, 2.) Jones' chromic acid reagent / .) cyclohexane, reflux, irradiated, 1.5 h, 2.) acetone, 0 deg C, 1 h
3: potassium carbonate / methanol; H2O / 1 h / Heating
4: toluene-p-sulphonic acid monohydrate / tetrahydrofuran / 1.5 h / Ambient temperature
5: 75 percent / zinc borohydride / 1,2-dimethoxy-ethane / 1.5 h / Heating
6: 38 percent / sodamide / toluene / 1.) room temperature, 10 min, 2.) reflux, 20 h
With
lead(IV) acetate; sodium tetrahydroborate; zinc borohydride; iodine; chromic acid; potassium carbonate; toluene-4-sulfonic acid; sodium amide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; toluene;
