1-[(benzyloxycarbonyl)methyl]-3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxopyrrolidine

Base Information

Chemical Name:1-[(benzyloxycarbonyl)methyl]-3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxopyrrolidine
CAS No.:250682-56-5
Molecular Formula:C₃₂H₃₄N₂O₆
Molecular Weight:542.632
Hs Code.:

Synonyms:1-[(benzyloxycarbonyl)methyl]-3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxopyrrolidine

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Chemical Property of 1-[(benzyloxycarbonyl)methyl]-3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxopyrrolidine

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Technology Process of 1-[(benzyloxycarbonyl)methyl]-3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxopyrrolidine

There total 4 articles about 1-[(benzyloxycarbonyl)methyl]-3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxopyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 250682-55-4
3-[(tert-butyloxycarbonyl)amino]3,5-dibenzyl-2,4-dioxopyrrolidine

: 5437-45-6
Benzyl bromoacetate

: 250682-56-5
1-[(benzyloxycarbonyl)methyl]-3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxopyrrolidine

Guidance literature:: 3-[(tert-butyloxycarbonyl)amino]3,5-dibenzyl-2,4-dioxopyrrolidine; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.25h;

Benzyl bromoacetate; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1021/jm9901531

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 250682-56-5
1-[(benzyloxycarbonyl)methyl]-3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxopyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. NaOH / dioxane / pH 10

2.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

2.2: 90 percent / tetrahydrofuran / 5 h / 20 °C

With sodium hydroxide; sodium hydride; In tetrahydrofuran; 1,4-dioxane; 1.1: Acylation / 2.1: Deprotonation / 2.2: Acylation;
DOI:10.1021/jm9901531

Reference yield:

: 3-amino-3,5-dibenzyl-pyrrolidine-2,4-dione

: 250682-56-5
1-[(benzyloxycarbonyl)methyl]-3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxopyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. NaOH / dioxane / pH 10

2.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

2.2: 90 percent / tetrahydrofuran / 5 h / 20 °C

With sodium hydroxide; sodium hydride; In tetrahydrofuran; 1,4-dioxane; 1.1: Acylation / 2.1: Deprotonation / 2.2: Acylation;
DOI:10.1021/jm9901531