3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxo-1-pyrrolidineacetic acid

Base Information

Chemical Name:3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxo-1-pyrrolidineacetic acid
CAS No.:250682-49-6
Molecular Formula:C₂₅H₂₈N₂O₆
Molecular Weight:452.507
Hs Code.:

Synonyms:3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxo-1-pyrrolidineacetic acid

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Chemical Property of 3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxo-1-pyrrolidineacetic acid

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Technology Process of 3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxo-1-pyrrolidineacetic acid

There total 5 articles about 3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxo-1-pyrrolidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 250682-56-5
1-[(benzyloxycarbonyl)methyl]-3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxopyrrolidine

: 250682-49-6
3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxo-1-pyrrolidineacetic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃;
DOI:10.1021/jm9901531

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 250682-49-6
3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxo-1-pyrrolidineacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. NaOH / dioxane / pH 10

2.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

2.2: 90 percent / tetrahydrofuran / 5 h / 20 °C

3.1: 95 percent / H₂ / 10 percent Pd/C / ethanol / 20 °C

With sodium hydroxide; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; 1.1: Acylation / 2.1: Deprotonation / 2.2: Acylation / 3.1: Hydrogenolysis;
DOI:10.1021/jm9901531

Reference yield:

: 3-amino-3,5-dibenzyl-pyrrolidine-2,4-dione

: 250682-49-6
3-[(tert-butyloxycarbonyl)amino]-3,5-dibenzyl-2,4-dioxo-1-pyrrolidineacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. NaOH / dioxane / pH 10

2.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

2.2: 90 percent / tetrahydrofuran / 5 h / 20 °C

3.1: 95 percent / H₂ / 10 percent Pd/C / ethanol / 20 °C

With sodium hydroxide; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; 1.1: Acylation / 2.1: Deprotonation / 2.2: Acylation / 3.1: Hydrogenolysis;
DOI:10.1021/jm9901531