(R_S,1S)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methyl-1-phenylethyl]amide

Base Information

• Chemical Name: (R_S,1S)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methyl-1-phenylethyl]amide
• CAS No.: 393536-64-6
• Molecular Formula: C₁₉H₃₅NO₂SSi
• Molecular Weight: 369.644

Synonyms:(R_S,1S)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methyl-1-phenylethyl]amide

Chemical Property of (R_S,1S)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methyl-1-phenylethyl]amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R_S,1S)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methyl-1-phenylethyl]amide

There total 2 articles about (R_S,1S)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methyl-1-phenylethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylmagnesium bromide + (RS)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methylethylidene]amide (393536-51-1) → (RS,1R)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methyl-1-phenylethyl]amide + (RS,1S)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methyl-1-phenylethyl]amide (393536-64-6)

Guidance literature:

With trimethylaluminum; In toluene; at -78 ℃; Title compound not separated from byproducts.;

DOI:10.1021/jo0156868

Reference yield:

1-(tert-butyldimethylsiloxy)-2-propanone (74685-00-0) → (RS,1S)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methyl-1-phenylethyl]amide (393536-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / Ti(OEt)4 / tetrahydrofuran / 70 °C

2: AlMe₃ / toluene / -78 °C

With titanium(IV) tetraethanolate; trimethylaluminum; In tetrahydrofuran; toluene; 2: Grignard reaction;

DOI:10.1021/jo0156868

Reference yield:

(RS,1S)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methyl-1-phenylethyl]amide (393536-64-6) → (S)-α-methylphenylglycinol (13398-53-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 0.5h;

DOI:10.1021/jo0156868

upstream raw materials:

(R_S)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methylethylidene]amide

1-(tert-butyldimethylsiloxy)-2-propanone

Downstream raw materials:

(S)-α-methylphenylglycinol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 393536-64-6 (R_S,1S)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methyl-1-phenylethyl]amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send