6-(dimethylamino)-2-{2-methyl-3-[1-methyl-5-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)-6-oxo-1,6-dihydropyridin-3-yl]phenyl}-1,2,3,4-tetrahydroisoquinolin-1-one

Base Information

Chemical Name:6-(dimethylamino)-2-{2-methyl-3-[1-methyl-5-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)-6-oxo-1,6-dihydropyridin-3-yl]phenyl}-1,2,3,4-tetrahydroisoquinolin-1-one
CAS No.:1178884-08-6
Molecular Formula:C₃₄H₃₆N₆O₄
Molecular Weight:592.698
Hs Code.:

6-(dimethylamino)-2-{2-methyl-3-[1-methyl-5-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)-6-oxo-1,6-dihydropyridin-3-yl]phenyl}-1,2,3,4-tetrahydroisoquinolin-1-one

Synonyms:6-(dimethylamino)-2-{2-methyl-3-[1-methyl-5-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)-6-oxo-1,6-dihydropyridin-3-yl]phenyl}-1,2,3,4-tetrahydroisoquinolin-1-one

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Chemical Property of 6-(dimethylamino)-2-{2-methyl-3-[1-methyl-5-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)-6-oxo-1,6-dihydropyridin-3-yl]phenyl}-1,2,3,4-tetrahydroisoquinolin-1-one

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Technology Process of 6-(dimethylamino)-2-{2-methyl-3-[1-methyl-5-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)-6-oxo-1,6-dihydropyridin-3-yl]phenyl}-1,2,3,4-tetrahydroisoquinolin-1-one

There total 9 articles about 6-(dimethylamino)-2-{2-methyl-3-[1-methyl-5-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)-6-oxo-1,6-dihydropyridin-3-yl]phenyl}-1,2,3,4-tetrahydroisoquinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1178884-41-7
2-(3-bromo-2-methylphenyl)-6-dimethylamino-3,4-dihydro-2H-isoquinolin-1-one

: 1178884-30-4
1-methyl-3-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-5-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-1H-pyridin-2-one

: 1178884-08-6
6-(dimethylamino)-2-{2-methyl-3-[1-methyl-5-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)-6-oxo-1,6-dihydropyridin-3-yl]phenyl}-1,2,3,4-tetrahydroisoquinolin-1-one

Guidance literature:: With potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In water; butan-1-ol; at 100 ℃; for 1.83333h; Inert atmosphere;

Reference yield:

: 700-84-5
5-fluoro-1-indanone

: 1178884-08-6
6-(dimethylamino)-2-{2-methyl-3-[1-methyl-5-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)-6-oxo-1,6-dihydropyridin-3-yl]phenyl}-1,2,3,4-tetrahydroisoquinolin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanesulfonic acid; sodium azide / dichloromethane / 2 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: ethanol / 7 h / 150 °C / Sealed tube

3.1: potassium carbonate / dimethyl sulfoxide / 24 h / 150 °C / Sealed tube; Inert atmosphere

3.2: 24 h / 150 °C / Sealed tube; Inert atmosphere

4.1: 2-(dicyclohexylphoshphino)-2',4',6'-triisopropyl-1,1'-biphenyl; bis(dibenzylideneacetone)-palladium⁽⁰⁾; potassium phosphate / water; butan-1-ol / 1.83 h / 100 °C / Inert atmosphere

With potassium phosphate; sodium azide; methanesulfonic acid; 2-(dicyclohexylphoshphino)-2',4',6'-triisopropyl-1,1'-biphenyl; potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethanol; dichloromethane; water; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm500305p

Reference yield:

: 214045-84-8
6-fluoro-3,4-dihydro-2H-isoquinolin-1-one

: 1178884-08-6
6-(dimethylamino)-2-{2-methyl-3-[1-methyl-5-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)-6-oxo-1,6-dihydropyridin-3-yl]phenyl}-1,2,3,4-tetrahydroisoquinolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 7 h / 150 °C / Sealed tube

2.1: potassium carbonate / dimethyl sulfoxide / 24 h / 150 °C / Sealed tube; Inert atmosphere

2.2: 24 h / 150 °C / Sealed tube; Inert atmosphere

3.1: 2-(dicyclohexylphoshphino)-2',4',6'-triisopropyl-1,1'-biphenyl; bis(dibenzylideneacetone)-palladium⁽⁰⁾; potassium phosphate / water; butan-1-ol / 1.83 h / 100 °C / Inert atmosphere

With potassium phosphate; 2-(dicyclohexylphoshphino)-2',4',6'-triisopropyl-1,1'-biphenyl; potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethanol; water; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm500305p