700-84-5

Basic information

• Product Name: 5-Fluoro-1-indanone
• Synonyms: 5-FLUORO-1-INDANONE;5-FLUORO-INDAN-1-ONE;5-Flouro-1-indanone;5-FLUOR-1-INDANON 99%;5-Fluoro-L-Indonone;5-fluoro-1-indonone;5-Fluoroindan-1-one 97%;5-Fluoroindan-1-one97%
• CAS NO: 700-84-5
• Molecular Formula: C₉H₇FO
• Molecular Weight: 150.15
• Product Categories: Indane/Indanone and Derivatives;indanone;Ketone;Fused Ring Systems;Halides;C9;Carbonyl Compounds;Ketones
• Mol File: 700-84-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 38-40 °C(lit.)
• Boiling Point: 113-114 °C(lit.)
• Flash Point: >230 °F
• Appearance: White to yellow/Crystalline Low Melting Solid
• Density: 1.216 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00109mmHg at 25°C
• Refractive Index: 1.459
• Storage Temp.: Refrigerator
• Water Solubility: insoluble
• BRN: 1617799
• CAS DataBase Reference: 5-Fluoro-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-1-indanone(700-84-5)
• EPA Substance Registry System: 5-Fluoro-1-indanone(700-84-5)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 700-84-5(Hazardous Substances Data)

Usage

Uses

5-Fluoro-1-indanone was used to prepare precursor for thiosemicarbazones derived from 1-indanones. It was used in the synthesis of 6-fluoro-1,2,3,4-tetrahydroquinoline hydrochloride.

InChI:InChI=1/C9H6F4O3/c10-8(11)9(12,13)16-6-3-1-2-5(4-6)7(14)15/h1-4,8H,(H,14,15)

Upstream product

• 828267-47-6 1-bromo-4-fluoro-2-vinylbenzene 
• 37530-82-8 5-fluoro-indan 
• 425704-52-5 methyl 3-(3-fluorophenyl)propanoate 
• 87087-34-1 3-(3-fluorophenyl)acrylic acid methyl ester 
• 20595-30-6 3-fluorocinnamic acid 
• 456-48-4 3-Fluorobenzaldehyde 
• 59223-73-3 diethyl 2-(3-fluorobenzyl)malonate 
• 462-06-6 fluorobenzene 
• 148960-31-0 3-(3-fluorophenyl)propionyl chloride 
• 458-45-7 3-(3-fluorophenyl)propionic acid 
• 347-93-3 3-chloro-4'-fluoropropiophenone 

Downstream Products

• 52085-92-4 5-fluoro-2,3-dihydro-1H-inden-1-ol 
• 111538-45-5 2-bromo-5-fluoro-1-indanone 
• 628732-48-9 5-fluoro-indan-1-carboxylic acid 
• 905725-09-9 C₁₅H₁₀Cl₂O₂ 
• 162751-93-1 (E)-5-fluoro-2-(hydroxyimino)-2,3-dihydroinden-1-one 
• 935681-01-9 4-bromo-5-fluoro-2,3-dihydro-1H-inden-1-one 
• 1438276-13-1 C₂₅H₂₅FOSi 
• 1438276-49-3 C₅₇H₆₅FO₆Si 
• 1443652-87-6 4-(diphenylmethyleneamino)-5-fluoro-2,3-dihydro-1H-inden-2-ol 
• 41201-58-5 5-Fluoro-2-Methyl-Indan-1-One 
• 2103399-35-3 (R)-5-fluoroindan-1-ylamine hydrochloride 

Relevant articles and documents

Development of a Flow Photochemical Aerobic Oxidation of Benzylic C-H Bonds

A continuous mesofluidic process has been developed for benzylic C-H oxidation with moderate to good yields using a photocatalyst (riboflavin tetraacetate, RFT) activated by a UV lamp and an iron additive [Fe(ClO4)2] via incorporation of singlet oxygen (1O2) for the direct formation of oxidized C=O or CH-OH compounds.

17a-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.

17α-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.