(R)-1-(4-Fluorophenyl)ethylamine hydrochloride

Base Information

• Chemical Name: (R)-1-(4-Fluorophenyl)ethylamine hydrochloride
• CAS No.: 321318-42-7
• Molecular Formula: C₈H₁₀FN*ClH
• Molecular Weight: 175.633
• Hs Code.: 2921499090
• Mol file: 321318-42-7.mol

Synonyms:Benzenemethanamine,4-fluoro-a-methyl-, hydrochloride, (aR)- (9CI);(R)-1-(4-Fluorophenyl)ethylaminehydrochloride;

Chemical Property of (R)-1-(4-Fluorophenyl)ethylamine hydrochloride

Chemical Property:

• PSA: 26.02000
• LogP: 3.34770
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-(4-Fluorophenyl)ethanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-(4-Fluorophenyl)ethylamine hydrochloride

There total 1 articles about (R)-1-(4-Fluorophenyl)ethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethynyl-4-fluorobenzene (766-98-3) → DL-4-fluoro-α-methylbenzylamine hydrochloride (403-37-2,321318-42-7,1419073-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver trifluoromethanesulfonate; water / methanol / 6 h / 120 °C

2.1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; ammonium formate / methanol / 12 h / 80 °C

2.2: Reflux

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); water; ammonium formate; silver trifluoromethanesulfonate; In methanol;

Reference yield: 51.0%

(R)-4-fluoro-β-methyl-benzylamine hydrochloride (321318-42-7,1419073-74-7) + 5-oxo-5H-chromeno[3,4-c]pyridine-8-carboxylic acid → (R)-N-(1-(4-fluorophenyl)ethyl)-5-oxo-5H-chromeno[3,4-c]pyridine-8-carboxamide

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield: 42.0%

(R)-4-fluoro-β-methyl-benzylamine hydrochloride (321318-42-7,1419073-74-7) + diformylhydrazine (628-36-4) → C10H10FN3

Guidance literature:

With pyridine; chloro-trimethyl-silane; triethylamine; at 80 ℃; for 15h;

upstream raw materials:

1-ethynyl-4-fluorobenzene