Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)-

Base Information

• Chemical Name: Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)-
• CAS No.: 310404-45-6
• Molecular Formula: C14H15 N O5
• Molecular Weight: 277.27
• Hs Code.: 2925190090
• Mol file: 310404-45-6.mol

Synonyms:Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)-

Chemical Property of Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 445.01°C at 760 mmHg
• Flash Point: 222.935°C
• PSA: 83.91000
• Density: 1.355g/cm³
• LogP: 1.65140

Purity/Quality:

NLT 98% ^*data from raw suppliers

Pentanoicacid,2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)-

There total 9 articles about Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

D-tert-butyl 2-phthalimid-N-oxy-4-methylpentanoate (380886-35-1) → (R)-4-methyl-2-phthalimidooxypentanoic acid (310404-45-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/ja029514j

Reference yield: 79.0%

benzyl (R)-4-methyl-2-phthalimidooxypentanoate (310404-40-1) → (R)-4-methyl-2-phthalimidooxypentanoic acid (310404-45-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 1h; under 760.051 Torr;

DOI:10.1021/jo0006573

Reference yield:

(S)-2-hydroxyl-3,3-dimethylbutyric acid (13748-90-8,498-36-2) → (R)-4-methyl-2-phthalimidooxypentanoic acid (310404-45-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 4 h / 60 °C

2: DMAP; DCC / CH₂Cl₂ / 12 h / 20 °C

3: K₂CO₃ / methanol; H₂O / 12 h / 20 °C

4: 70 percent / DEAD; PPh₃ / tetrahydrofuran

5: TFA / CH₂Cl₂ / 1 h / 20 °C

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1021/jo010376a

upstream raw materials:

benzyl (R)-4-methyl-2-phthalimidooxypentanoate

D-tert-butyl 2-phthalimid-N-oxy-4-methylpentanoate

L-leucine

(S)-2-hydroxyl-3,3-dimethylbutyric acid

Downstream raw materials:

(S)-2-[(R)-2-((R)-2-Benzyloxycarbonylamino-propionylaminooxy)-4-methyl-pentanoylaminooxy]-3-phenyl-propionic acid tert-butyl ester

(S)-2-[(R)-2-((S)-2-Benzyloxycarbonylamino-propionylaminooxy)-4-methyl-pentanoylaminooxy]-3-phenyl-propionic acid tert-butyl ester