Technology Process of benzyl (R)-4-methyl-2-phthalimidooxypentanoate
There total 3 articles about benzyl (R)-4-methyl-2-phthalimidooxypentanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
dichloromethane;
at -40 - -20 ℃;
for 0.666667h;
DOI:10.1021/jo0006573
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: NaNO2; 2.5N H2SO4 / H2O / 0 - 20 °C
2.1: Cs2CO3 / methanol; H2O / pH 7
2.2: 93 percent / dimethylformamide / 6 h / 20 °C
3.1: 99 percent / PPh3; DIAD / CH2Cl2 / 0.67 h / -40 - -20 °C
With
di-isopropyl azodicarboxylate; sulfuric acid; caesium carbonate; triphenylphosphine; sodium nitrite;
In
methanol; dichloromethane; water;
1.1: Substitution / 2.1: deprotonation / 2.2: benzylation / 3.1: Substitution;
DOI:10.1021/jo0006573
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Cs2CO3 / methanol; H2O / pH 7
1.2: 93 percent / dimethylformamide / 6 h / 20 °C
2.1: 99 percent / PPh3; DIAD / CH2Cl2 / 0.67 h / -40 - -20 °C
With
di-isopropyl azodicarboxylate; caesium carbonate; triphenylphosphine;
In
methanol; dichloromethane; water;
1.1: deprotonation / 1.2: benzylation / 2.1: Substitution;
DOI:10.1021/jo0006573
