2-(5-methyl-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide

Base Information

Chemical Name:2-(5-methyl-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide
CAS No.:1449580-84-0
Molecular Formula:C₂₅H₂₇N₅O₂
Molecular Weight:429.522
Hs Code.:

Synonyms:2-(5-methyl-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide

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Chemical Property of 2-(5-methyl-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide

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Technology Process of 2-(5-methyl-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide

There total 12 articles about 2-(5-methyl-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: C₃₀H₃₅N₅O₄

: 1449580-84-0
2-(5-methyl-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide

Guidance literature:: C₃₀H₃₅N₅O₄; With trifluorormethanesulfonic acid; In dichloromethane; at 25 ℃; for 6h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 42.0%

: C₃₉H₄₅N₅O₆

: 1449580-84-0
2-(5-methyl-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; at 25 ℃; for 6h;

Reference yield:

: 60956-25-4
2-bromo-1,3-dimethyl-4-nitrobenzene

: 1449580-84-0
2-(5-methyl-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1: pyrrolidine / N,N-dimethyl acetamide / 120 °C / Sealed tube

2: acetic acid; zinc / water / 0 - 110 °C

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 0.67 h / 180 °C / Microwave irradiation

4: water; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; acetonitrile / 6 h / 90 °C / Inert atmosphere

5: trifluorormethanesulfonic acid / dichloromethane / 6 h / 25 °C

With pyrrolidine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; trifluorormethanesulfonic acid; water; potassium acetate; potassium carbonate; acetic acid; zinc; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; acetonitrile;