Propanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-, (2R)-

Base Information

• Chemical Name: Propanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-, (2R)-
• CAS No.: 310404-43-4
• Molecular Formula: C11H9 N O5
• Molecular Weight: 235.196
• Hs Code.: 2925190090
• Mol file: 310404-43-4.mol

Synonyms:Propanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-, (2R)-

Chemical Property of Propanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-, (2R)-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 428.769°C at 760 mmHg
• Flash Point: 213.112°C
• PSA: 83.91000
• Density: 1.515g/cm³
• LogP: 0.62520

Purity/Quality:

>98% ^*data from raw suppliers

(2R)-2-[(1,3-DIHYDRO-1,3-DIOXO-2H-ISOINDOL-2-YL)OXY]-PROPANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-, (2R)-

There total 3 articles about Propanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-hydroxyphthalimide (524-38-9) + (S)-2-bromopropanoic acid (32644-15-8,10327-08-9) → (R)-2-phthalimidooxypropanoic acid (310404-43-4)

Guidance literature:

N-hydroxyphthalimide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

(S)-2-bromopropanoic acid; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; N,N-dimethyl-formamide; mineral oil; Cooling with ice;

DOI:10.1021/jo901612j

Reference yield:

(R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-propionic acid benzyl ester → (R)-2-phthalimidooxypropanoic acid (310404-43-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 1h; under 760.051 Torr;

DOI:10.1021/jo0006573

Reference yield:

(R)-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)oxy)propanoate (380886-36-2) → (R)-2-phthalimidooxypropanoic acid (310404-43-4)

Guidance literature:

With trifluoroacetic acid; at 0 ℃; for 2h;

DOI:10.1016/j.bmcl.2005.04.050

upstream raw materials:

(R)-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)oxy)propanoate

N-hydroxyphthalimide

(S)-2-bromopropanoic acid

Downstream raw materials:

D-AOAla-OH hydrochloride