tricyclo<3.3.1.1^3,7>dec-2-yl -<2-<<1-(hydroxymethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-2-ethoyethyl>carbamate

Base Information

• Chemical Name: tricyclo<3.3.1.1^3,7>dec-2-yl -<2-<<1-(hydroxymethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-2-ethoyethyl>carbamate
• CAS No.: 139657-08-2
• Molecular Formula: C₃₁H₃₇N₃O₄
• Molecular Weight: 515.652

Synonyms:tricyclo<3.3.1.1^3,7>dec-2-yl -<2-<<1-(hydroxymethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-2-ethoyethyl>carbamate

Chemical Property of tricyclo<3.3.1.1^3,7>dec-2-yl -<2-<<1-(hydroxymethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-2-ethoyethyl>carbamate

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of tricyclo<3.3.1.1^3,7>dec-2-yl -<2-<<1-(hydroxymethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-2-ethoyethyl>carbamate

There total 3 articles about tricyclo<3.3.1.1^3,7>dec-2-yl -<2-<<1-(hydroxymethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-2-ethoyethyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

L-Phenylalaninol (3182-95-4) + tricyclo<3.3.1.13,7>dec-2-yl <1-carboxy-2-(1H-indol-3-yl)ethyl>carbamate (139657-07-1) → tricyclo<3.3.1.13,7>dec-2-yl -<2-<<1-(hydroxymethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-2-ethoyethyl>carbamate (139657-08-2)

Guidance literature:

With 2,3,4,5,6-pentafluorophenol; dicyclohexyl-carbodiimide; In ethyl acetate; at 40 ℃; for 18h;

DOI:10.1021/jm00086a017

Reference yield:

2-adamantyl chloroformate (53120-53-9) → tricyclo<3.3.1.13,7>dec-2-yl -<2-<<1-(hydroxymethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-2-ethoyethyl>carbamate (139657-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / NaHCO₃, NaOH / dioxane / 18 h / Ambient temperature

2: 71 percent / N,N'-dicyclohexylcarbodiimide (DCC), pentafluorophenol (PFP) / ethyl acetate / 18 h / 40 °C

With sodium hydroxide; 2,3,4,5,6-pentafluorophenol; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In 1,4-dioxane; ethyl acetate;

DOI:10.1021/jm00086a017

Reference yield:

D-tryptophan (153-94-6,27732-43-0,80206-30-0,27813-82-7) → tricyclo<3.3.1.13,7>dec-2-yl -<2-<<1-(hydroxymethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-2-ethoyethyl>carbamate (139657-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / NaHCO₃, NaOH / dioxane / 18 h / Ambient temperature

2: 71 percent / N,N'-dicyclohexylcarbodiimide (DCC), pentafluorophenol (PFP) / ethyl acetate / 18 h / 40 °C

With sodium hydroxide; 2,3,4,5,6-pentafluorophenol; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In 1,4-dioxane; ethyl acetate;

DOI:10.1021/jm00086a017

upstream raw materials:

L-Phenylalaninol

tricyclo<3.3.1.1^3,7>dec-2-yl <1-carboxy-2-(1H-indol-3-yl)ethyl>carbamate

2-adamantyl chloroformate

D-tryptophan

Downstream raw materials:

tricyclo<3.3.1.1^3,7>dec-2-yl <1-<4,5-dihydro-4-(phenylmethyl)-2-thiazolyl>-2-(1H-indol3-yl)ethyl>carbamate

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