53120-53-9Relevant articles and documents
Versatile Cp*Co(III)(LX) Catalyst System for Selective Intramolecular C-H Amidation Reactions
Chang, Sukbok,Jung, Hoimin,Kim, Dongwook,Lee, Jeonghyo,Lee, Jia,Park, Juhyeon
supporting information, p. 12324 - 12332 (2020/08/06)
Herein, we report the development of a tailored cobalt catalyst system of Cp*Co(III)(LX) toward intramolecular C-H nitrene insertion of azidoformates to afford cyclic carbamates. The cobalt complexes were easy to prepare and bench-stable, thus offering a convenient reaction protocol. The catalytic reactivity was significantly improved by the electronic tuning of the bidentate LX ligands, and the observed regioselectivity was rationalized by the conformational analysis and DFT calculations of the transition states. The superior performance of the newly developed cobalt catalyst system could be broadly applied to both C(sp2)-H and C(sp3)-H carbamation reactions under mild conditions.
INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
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Page/Page column 33, (2011/02/26)
This invention relates to novel compounds of the Formula (I*), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11
Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1
Tice, Colin M.,Zhao, Wei,Krosky, Paula M.,Kruk, Barbara A.,Berbaum, Jennifer,Johnson, Judith A.,Bukhtiyarov, Yuri,Panemangalore, Reshma,Scott, Boyd B.,Zhao, Yi,Bruno, Joseph G.,Howard, Lamont,Togias, Jennifer,Ye, Yuan-Jie,Singh, Suresh B.,McKeever, Brian M.,Lindblom, Peter R.,Guo, Joan,Guo, Rong,Nar, Herbert,Schuler-Metz, Annette,Gregg, Richard E.,Leftheris, Katerina,Harrison, Richard K.,McGeehan, Gerard M.,Zhuang, Linghang,Claremon, David A.
scheme or table, p. 6725 - 6729 (2011/01/12)
Synthesis of 2-adamantyl carbamate derivatives of piperidines and pyrrolidines led to the discovery of 9a with an IC50 of 15.2 nM against human 11β-HSD1 in adipocytes. Optimization for increased adipocyte potency, metabolic stability and select
