ethyl (rac)-7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate

Base Information

Chemical Name:ethyl (rac)-7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate
CAS No.:1234619-31-8
Molecular Formula:C₃₁H₂₁F₃N₆O₄
Molecular Weight:598.541
Hs Code.:

ethyl (rac)-7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate

Synonyms:ethyl (rac)-7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate

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Chemical Property of ethyl (rac)-7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate

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Technology Process of ethyl (rac)-7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate

There total 3 articles about ethyl (rac)-7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1234620-68-8
Ethyl 7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1234619-31-8
ethyl (rac)-7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate

Guidance literature:: With pyridine; copper diacetate; triethylamine; In dichloromethane; for 36h; Molecular sieve; Inert atmosphere;

Reference yield:

: 1234620-67-7
ethyl 2-amino-7-(4-cyanophenyl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate

: 1234619-31-8
ethyl (rac)-7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; pyridine / toluene / 12 h / Inert atmosphere; Reflux

2: triethylamine; pyridine; copper diacetate / dichloromethane / 36 h / Molecular sieve; Inert atmosphere

With pyridine; copper diacetate; triethylamine; In dichloromethane; toluene;

Reference yield:

: 89809-67-6
ethyl (E/Z)-2-(4-cyanobenzylidene)-3-oxobutanoate

: 1234619-31-8
ethyl (rac)-7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 63 °C / Inert atmosphere

2: triethylamine; pyridine / toluene / 12 h / Inert atmosphere; Reflux

3: triethylamine; pyridine; copper diacetate / dichloromethane / 36 h / Molecular sieve; Inert atmosphere

With pyridine; copper diacetate; sodium hydrogencarbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;