2-({7-(4-Cyanophenyl)-6-(ethoxycarbonyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamoyl)benzoic acid

Base Information

Chemical Name:2-({7-(4-Cyanophenyl)-6-(ethoxycarbonyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamoyl)benzoic acid
CAS No.:1234619-41-0
Molecular Formula:C₃₁H₂₃F₃N₆O₅
Molecular Weight:616.556
Hs Code.:

2-({7-(4-Cyanophenyl)-6-(ethoxycarbonyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamoyl)benzoic acid

Synonyms:2-({7-(4-Cyanophenyl)-6-(ethoxycarbonyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamoyl)benzoic acid

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Chemical Property of 2-({7-(4-Cyanophenyl)-6-(ethoxycarbonyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamoyl)benzoic acid

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Technology Process of 2-({7-(4-Cyanophenyl)-6-(ethoxycarbonyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamoyl)benzoic acid

There total 4 articles about 2-({7-(4-Cyanophenyl)-6-(ethoxycarbonyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1234619-31-8
ethyl (rac)-7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate

: 1234619-41-0
2-({7-(4-Cyanophenyl)-6-(ethoxycarbonyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamoyl)benzoic acid

Guidance literature:: ethyl (rac)-7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate; With potassium carbonate; In ethanol; water; at 50 ℃;

With hydrogenchloride; In ethanol; water;

Reference yield:

: 1234620-68-8
Ethyl 7-(4-cyanophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate

: 1234619-41-0
2-({7-(4-Cyanophenyl)-6-(ethoxycarbonyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; pyridine; copper diacetate / dichloromethane / 36 h / Molecular sieve; Inert atmosphere

2: potassium carbonate / ethanol; water / 50 °C

With pyridine; copper diacetate; potassium carbonate; triethylamine; In ethanol; dichloromethane; water;

Reference yield:

: 1234620-67-7
ethyl 2-amino-7-(4-cyanophenyl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate

: 1234619-41-0
2-({7-(4-Cyanophenyl)-6-(ethoxycarbonyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; pyridine / toluene / 12 h / Inert atmosphere; Reflux

2: triethylamine; pyridine; copper diacetate / dichloromethane / 36 h / Molecular sieve; Inert atmosphere

3: potassium carbonate / ethanol; water / 50 °C

With pyridine; copper diacetate; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; toluene;