4-(2-Chloroethoxy)phenol

Base Information

• Chemical Name: 4-(2-Chloroethoxy)phenol
• CAS No.: 100238-55-9
• Molecular Formula: C8H9 Cl O2
• Molecular Weight: 172.611
• Hs Code.: 2909500000
• European Community (EC) Number: 600-043-0
• DSSTox Substance ID: DTXSID60544213
• Nikkaji Number: J3.280.952I
• Wikidata: Q82421262
• Mol file: 100238-55-9.mol

Synonyms:4-(2-CHLOROETHOXY)PHENOL;100238-55-9;Phenol, 4-(2-chloroethoxy)-;SCHEMBL2767353;DTXSID60544213;AKOS006291643;CS-0000181;2-NAPHTHOL-8-SULFONICACIDPOTASSIUMSALT

Chemical Property of 4-(2-Chloroethoxy)phenol

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 301.819°C at 760 mmHg
• Flash Point: 136.335°C
• PSA: 29.46000
• Density: 1.235g/cm³
• LogP: 2.00980
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 172.0291072
• Heavy Atom Count: 11
• Complexity: 100

Purity/Quality:

99.9% ^*data from raw suppliers

4-(2-CHLOROETHOXY)PHENOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1O)OCCCl

Technology Process of 4-(2-Chloroethoxy)phenol

There total 5 articles about 4-(2-Chloroethoxy)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(2-chloroethoxy)phenyl acetate → 4-(2-chloroethoxy)phenol (100238-55-9)

Guidance literature:

4-(2-chloroethoxy)phenyl acetate; With acetyl chloride; In methanol; at 0 - 20 ℃; for 16h;

With water; In methanol; at -18 - 60 ℃; for 16h;

DOI:10.1007/s11172-017-1732-9

Reference yield: 85.0%

4-(2-chloroethoxy)benzaldehyde (54373-15-8) → 4-(2-chloroethoxy)phenol (100238-55-9)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; In methanol; water; at 20 ℃; for 44h; Cooling with ice;

DOI:10.1007/s11172-017-1732-9

Reference yield: 84.0%

1-(2-chloroethoxy)-4-methoxybenzene (3383-74-2) → 4-(2-chloroethoxy)phenol (100238-55-9)

Guidance literature:

With aluminum (III) chloride; tetramethlyammonium chloride; In dichloromethane; for 30h; Reflux;

DOI:10.1007/s11172-017-1732-9

upstream raw materials:

1-Bromo-2-chloroethane

hydroquinone

4-(2-chloroethoxy)benzaldehyde

1-(2-chloroethoxy)-4-methoxybenzene

Downstream raw materials:

1-(2-Chloroethoxy)-4-<2-(2-chloroethoxy)ethoxy>benzene

C₄₈H₄₈Cl₆N₃O₁₂P₃

4-(2-chloroethoxy)phenyl 3,5-di-O-benzoyl-2-O-chloroacetyl-α-D-arabinofuranoside

4-(2-chloroethoxy)phenyl 2,3,5-tri-O-benzoyl-α-D-arabinofuranoside