2-amino-5-[4-(benzyloxy)benzoyl]-4-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrole-3-carboxamide

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Chemical Name:2-amino-5-[4-(benzyloxy)benzoyl]-4-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrole-3-carboxamide
CAS No.:1266682-66-9
Molecular Formula:C₃₃H₂₉N₃O₅
Molecular Weight:547.61
Hs Code.:

Synonyms:2-amino-5-[4-(benzyloxy)benzoyl]-4-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrole-3-carboxamide

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Chemical Property of 2-amino-5-[4-(benzyloxy)benzoyl]-4-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrole-3-carboxamide

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Technology Process of 2-amino-5-[4-(benzyloxy)benzoyl]-4-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrole-3-carboxamide

There total 3 articles about 2-amino-5-[4-(benzyloxy)benzoyl]-4-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 1266682-62-5
N-(2-(4-(benzyloxy)phenyl)-2-oxoethyl)methanesulfonamide

: 107-91-5
cyanoacetic acid amide

: 1266682-66-9
2-amino-5-[4-(benzyloxy)benzoyl]-4-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrole-3-carboxamide

Guidance literature:: With potassium carbonate; In ethanol; for 14h; Reflux; Inert atmosphere;
DOI:10.1021/ol103149b

Reference yield:

: 4195-25-9
2-amino-1-(4-benzyloxyphenyl)ethanone hydrochloride

: 1266682-66-9
2-amino-5-[4-(benzyloxy)benzoyl]-4-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / water; acetone / 10.5 h / 20 °C / Cooling with ice

2: potassium carbonate / ethanol / 14 h / Reflux; Inert atmosphere

With potassium carbonate; triethylamine; In ethanol; water; acetone;
DOI:10.1021/ol103149b