6-[4-(benzyloxy)benzoyl]-5-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

Base Information

Chemical Name:6-[4-(benzyloxy)benzoyl]-5-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione
CAS No.:1266682-70-5
Molecular Formula:C₃₄H₂₇N₃O₆
Molecular Weight:573.605
Hs Code.:

Synonyms:6-[4-(benzyloxy)benzoyl]-5-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

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Chemical Property of 6-[4-(benzyloxy)benzoyl]-5-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

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Technology Process of 6-[4-(benzyloxy)benzoyl]-5-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

There total 4 articles about 6-[4-(benzyloxy)benzoyl]-5-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 79-37-8
oxalyl dichloride

: 1266682-66-9
2-amino-5-[4-(benzyloxy)benzoyl]-4-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrole-3-carboxamide

: 1266682-70-5
6-[4-(benzyloxy)benzoyl]-5-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

Guidance literature:: In dichloromethane; diethylene glycol dimethyl ether; at 110 - 130 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ol103149b

Reference yield:

: 1266682-62-5
N-(2-(4-(benzyloxy)phenyl)-2-oxoethyl)methanesulfonamide

: 1266682-70-5
6-[4-(benzyloxy)benzoyl]-5-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / ethanol / 14 h / Reflux; Inert atmosphere

2: dichloromethane; diethylene glycol dimethyl ether / 6 h / 110 - 130 °C / Inert atmosphere

With potassium carbonate; In ethanol; dichloromethane; diethylene glycol dimethyl ether;
DOI:10.1021/ol103149b

Reference yield:

: 4195-25-9
2-amino-1-(4-benzyloxyphenyl)ethanone hydrochloride

: 1266682-70-5
6-[4-(benzyloxy)benzoyl]-5-[4-(benzyloxy)-3-methoxyphenyl]-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / water; acetone / 10.5 h / 20 °C / Cooling with ice

2: potassium carbonate / ethanol / 14 h / Reflux; Inert atmosphere

3: dichloromethane; diethylene glycol dimethyl ether / 6 h / 110 - 130 °C / Inert atmosphere

With potassium carbonate; triethylamine; In ethanol; dichloromethane; diethylene glycol dimethyl ether; water; acetone;
DOI:10.1021/ol103149b