2-(7-trifluoromethylquinolin-4-ylamino)benzoic acid N'-(2-chloroacetyl)hydrazide

Base Information

Chemical Name:2-(7-trifluoromethylquinolin-4-ylamino)benzoic acid N'-(2-chloroacetyl)hydrazide
CAS No.:864832-48-4
Molecular Formula:C₁₉H₁₄ClF₃N₄O₂
Molecular Weight:422.794
Hs Code.:

Synonyms:2-(7-trifluoromethylquinolin-4-ylamino)benzoic acid N'-(2-chloroacetyl)hydrazide

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Chemical Property of 2-(7-trifluoromethylquinolin-4-ylamino)benzoic acid N'-(2-chloroacetyl)hydrazide

Chemical Property:

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Technology Process of 2-(7-trifluoromethylquinolin-4-ylamino)benzoic acid N'-(2-chloroacetyl)hydrazide

There total 3 articles about 2-(7-trifluoromethylquinolin-4-ylamino)benzoic acid N'-(2-chloroacetyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 864832-47-3
2-(7-trifluoromethylquinolin-4-ylamino)benzoic acid hydrazide

: 79-04-9
chloroacetyl chloride

: 864832-48-4
2-(7-trifluoromethylquinolin-4-ylamino)benzoic acid N'-(2-chloroacetyl)hydrazide

Guidance literature:: With triethylamine; In benzene; for 10h; Heating;
DOI:10.1016/j.bmc.2005.05.053

Reference yield:

: 2-(7-trifluoromethyl-quinolin-4-ylamino)-benzoyl chloride

: 864832-48-4
2-(7-trifluoromethylquinolin-4-ylamino)benzoic acid N'-(2-chloroacetyl)hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 6 h / Heating

2: 43 percent / triethylamine / benzene / 10 h / Heating

With hydrazine hydrate; triethylamine; In ethanol; benzene;
DOI:10.1016/j.bmc.2005.05.053

Reference yield:

: 36777-15-8
2-(7-trifluoromethyl-4-quinolylamino)benzoic acid

: 864832-48-4
2-(7-trifluoromethylquinolin-4-ylamino)benzoic acid N'-(2-chloroacetyl)hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 4 h / Heating

2: hydrazine hydrate / ethanol / 6 h / Heating

3: 43 percent / triethylamine / benzene / 10 h / Heating

With thionyl chloride; hydrazine hydrate; triethylamine; In ethanol; benzene;
DOI:10.1016/j.bmc.2005.05.053