[2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone

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Chemical Name:[2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone
CAS No.:1224639-71-7
Molecular Formula:C₂₃H₁₈BrCl₂N₃O₂
Molecular Weight:519.225
Hs Code.:

Synonyms:[2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone

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Chemical Property of [2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone

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Technology Process of [2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone

There total 8 articles about [2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1224640-13-4
1-cyclopropyl-1,2,3,4-tetrahydro-quinoxaline

: 1224640-17-8
2-(4-bromo-2,5-dichloro phenoxy)nicotinic acid

: 1224639-71-7
[2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone

Guidance literature:: 2-(4-bromo-2,5-dichloro phenoxy)nicotinic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 0.166667h;

1-cyclopropyl-1,2,3,4-tetrahydro-quinoxaline; In dichloromethane; at 20 ℃;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1224639-71-7
[2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 19 h / 20 - 30 °C

2.1: triethylamine / dichloromethane / 72 h / 0 - 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 900.09 Torr

4.1: borane-THF / tetrahydrofuran / 20 °C

5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

5.2: 20 °C

With borane-THF; palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/cmdc.201200474

Reference yield:

: 55432-23-0
cyclopropyl-(2-nitro-phenyl)-amine

: 1224639-71-7
[2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 72 h / 0 - 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 900.09 Torr

3.1: borane-THF / tetrahydrofuran / 20 °C

4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

4.2: 20 °C

With borane-THF; palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/cmdc.201200474