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1-Cyclopropyl-1,2,3,4-tetrahydroquinoxaline is an organic compound characterized by its unique cyclopropyl and quinoxaline structures. It is a heterocyclic compound with potential applications in various fields due to its chemical properties and reactivity.

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  • 1224640-13-4 Structure
  • Basic information

    1. Product Name: 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline
    2. Synonyms: 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline
    3. CAS NO:1224640-13-4
    4. Molecular Formula: C11H14N2
    5. Molecular Weight: 174.24226
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1224640-13-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline(1224640-13-4)
    11. EPA Substance Registry System: 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline(1224640-13-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1224640-13-4(Hazardous Substances Data)

1224640-13-4 Usage

Uses

Used in Organic Synthesis:
1-Cyclopropyl-1,2,3,4-tetrahydroquinoxaline is used as a reactant and reagent in organic synthesis for its ability to participate in a wide range of chemical reactions. Its unique structure allows it to be a versatile building block for the creation of more complex organic molecules.
Used in Pharmaceutical Industry:
1-Cyclopropyl-1,2,3,4-tetrahydroquinoxaline is used as an intermediate in the synthesis of various pharmaceutical compounds. Its reactivity and structural diversity make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
1-Cyclopropyl-1,2,3,4-tetrahydroquinoxaline is also used in chemical research as a model compound to study the properties and reactivity of cyclopropyl and quinoxaline-containing molecules. This helps researchers understand the behavior of these structures and develop new synthetic strategies and applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1224640-13-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,4,6,4 and 0 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1224640-13:
(9*1)+(8*2)+(7*2)+(6*4)+(5*6)+(4*4)+(3*0)+(2*1)+(1*3)=114
114 % 10 = 4
So 1224640-13-4 is a valid CAS Registry Number.

1224640-13-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-cyclopropyl-2,3-dihydro-1H-quinoxaline

1.2 Other means of identification

Product number -
Other names 1-cyclopropyl-1,2,3,4-tetrahydro-quinoxaline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1224640-13-4 SDS

1224640-13-4Downstream Products

1224640-13-4Relevant articles and documents

Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists

Chen, Wei-Dong,Fu, Yajie,Hou, Ruifang,Li, Yunfu,Wang, Chenwei,Wang, Jie,Wang, Le,Wang, Yan-Dong,Yang, Dongbin,Zhao, Shizhen,Zheng, Shaowei

, p. 3618 - 3629 (2022/02/11)

TGR5 is emerging as an important and promising target for the treatment of non-alcoholic steatohepatitis, type 2 diabetes mellitus (T2DM), and obesity. A series of novel 3-phenoxypyrazine-2-carboxamide derivatives were designed, synthesized and evaluated

Design, synthesis and evaluation of 1-benzyl-1H-imidazole-5-carboxamide derivatives as potent TGR5 agonists

Zhao, Shizhen,Li, Xinping,Wang, Le,Peng, Wenjing,Ye, Wenling,Li, Weiguo,Wang, Yan-Dong,Chen, Wei-Dong

, (2021/01/18)

TGR5 is emerging as an important and promising target for the treatment of diabetes, obesity and other metabolic syndromes. A series of novel 1-benzyl-1H-imidazole-5-carboxamide derivatives was designed, synthesized and evaluated in vitro and in vivo. The

2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5)

Martin, Rainer E.,Bissantz, Caterina,Gavelle, Olivier,Kuratli, Christoph,Dehmlow, Henrietta,Richter, Hans G. F.,ObstSander, Ulrike,Erickson, Shawn D.,Kim, Kyungjin,Pietranico-Cole, Sherrie Lynn,Alvarez-Sanchez, Ruben,Ullmer, Christoph

, p. 569 - 576 (2013/08/22)

Potency with potential: 2-Phenoxy- nicotinamides were identified as potent agonists at the GPBAR1 receptor, a target in the treatment of obesity, type2 diabetes and metabolic syndrome. Extensive structure-activity relationship studies supported by homolog

NON-SYSTEMIC TGR5 AGONISTS

-

, (2013/07/05)

Compounds of structure (I), or a stereoisomer, tautomer, pharmaceutically acceptable salt or prodrug thereof, wherein R1, R2, R3, R4, R8, R9, R10, R11, R12, A1, A2, X, Y and Z are as defined herein. Uses of such compounds as TGR5 antagonists and for treatment of various indications, including Type II diabetes meletus are also provided.

4-PHENOXY-NICOTINAMIDE OR 4-PHENOXY-PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS

-

, (2011/08/04)

This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.

4-PHENOXY-NICOTINAMIDE OR 4-PHENOXY-PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS

-

, (2011/08/08)

This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula (I), wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.

NOVEL PHENYL AMIDE OR PYRIDYL AMIDE DERIVATIVES

-

Page/Page column 48, (2010/05/13)

This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.

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