1224640-13-4

Basic information

• Product Name: 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline
• Synonyms: 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline
• CAS NO: 1224640-13-4
• Molecular Formula: C₁₁H₁₄N₂
• Molecular Weight: 174.24226
• Mol File: 1224640-13-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline(1224640-13-4)
• EPA Substance Registry System: 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline(1224640-13-4)

Safety Data

• Hazardous Substances Data: 1224640-13-4(Hazardous Substances Data)

Usage

Uses

1-Cyclopropyl-1,2,3,4-tetrahydroquinoxaline is a useful reactant and reagent in organic reactions and synthesis.

Upstream product

• 55432-23-0 cyclopropyl-(2-nitro-phenyl)-amine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 1224640-12-3 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-2,3-dione 
• 1224640-11-2 1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione 
• 1224640-10-1 N-cyclopropyl-N-(2-nitro-phenyl)-oxalamic acid methyl ester 

Downstream Products

• 1224639-33-1 (4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[2-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone 
• 1224639-71-7 [2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone 
• 1315468-81-5 2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoic acid methyl ester 
• 1315468-83-7 4-chloro-5-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phthalic acid dimethyl ester 
• 1315468-84-8 {2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-acetic acid methyl ester 
• 1315468-85-9 {2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-acetic acid 
• 1315468-88-2 3-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-propionic acid ethyl ester 
• 1315468-89-3 3-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-propionic acid 
• 1315468-90-6 2-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-ethanesulfonic acid 
• 1315468-93-9 2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-N-(1 H-tetrazol-5-yl)-benzamide 
• 1315469-13-6 2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzamide 
• 1315469-16-9 (4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxymethyl-phenoxy)-pyridin-3-yl]-methanone 
• 1315469-17-0 2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzonitrile 
• 1315469-18-1 (4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxy-phenoxy)-pyridin-3-yl]-methanone 

Relevant articles and documents

Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists

TGR5 is emerging as an important and promising target for the treatment of non-alcoholic steatohepatitis, type 2 diabetes mellitus (T2DM), and obesity. A series of novel 3-phenoxypyrazine-2-carboxamide derivatives were designed, synthesized and evaluated

2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5)

Potency with potential: 2-Phenoxy- nicotinamides were identified as potent agonists at the GPBAR1 receptor, a target in the treatment of obesity, type2 diabetes and metabolic syndrome. Extensive structure-activity relationship studies supported by homolog

4-PHENOXY-NICOTINAMIDE OR 4-PHENOXY-PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS

This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.