2-amino-9-[2-(mesitylcarbonyl)-3,3-dimethylisoxazolidin-5-yl]-1,9-dihydro-6H-purin-6-one

Base Information

Chemical Name:2-amino-9-[2-(mesitylcarbonyl)-3,3-dimethylisoxazolidin-5-yl]-1,9-dihydro-6H-purin-6-one
CAS No.:1448227-79-9
Molecular Formula:C₂₀H₂₄N₆O₃
Molecular Weight:396.449
Hs Code.:

Synonyms:2-amino-9-[2-(mesitylcarbonyl)-3,3-dimethylisoxazolidin-5-yl]-1,9-dihydro-6H-purin-6-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-9-[2-(mesitylcarbonyl)-3,3-dimethylisoxazolidin-5-yl]-1,9-dihydro-6H-purin-6-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-amino-9-[2-(mesitylcarbonyl)-3,3-dimethylisoxazolidin-5-yl]-1,9-dihydro-6H-purin-6-one

There total 4 articles about 2-amino-9-[2-(mesitylcarbonyl)-3,3-dimethylisoxazolidin-5-yl]-1,9-dihydro-6H-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 73-40-5
2-amino-1,9-dihydro-6H-purin-6-one

: 1416969-41-9
N-mesitoyl-3,3-dimethyl-5-acetoxy-1,2-isoxazolidine

: 1448227-79-9
2-amino-9-[2-(mesitylcarbonyl)-3,3-dimethylisoxazolidin-5-yl]-1,9-dihydro-6H-purin-6-one

Guidance literature:: 2-amino-1,9-dihydro-6H-purin-6-one; With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane; Inert atmosphere; Reflux;

N-mesitoyl-3,3-dimethyl-5-acetoxy-1,2-isoxazolidine; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; Inert atmosphere; Reflux;
DOI:10.1055/s-0032-1316916

Reference yield:

: 2904-57-6
mesitylenecarbonitrile oxide

: 1448227-79-9
2-amino-9-[2-(mesitylcarbonyl)-3,3-dimethylisoxazolidin-5-yl]-1,9-dihydro-6H-purin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methylmorpholine N-oxide / dichloromethane / 20 °C / Cooling with ice

2.1: dmap; triethylamine / dichloromethane / 20 °C / Cooling with ice

3.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / Inert atmosphere; Reflux

3.2: 0 °C / Inert atmosphere; Reflux

With dmap; N,O-bis-(trimethylsilyl)-acetamide; 4-methylmorpholine N-oxide; triethylamine; In dichloromethane;
DOI:10.1055/s-0032-1316916

Reference yield:

: 40188-34-9
2,4,6-trimethylbenzaldehyde oxime

: 1448227-79-9
2-amino-9-[2-(mesitylcarbonyl)-3,3-dimethylisoxazolidin-5-yl]-1,9-dihydro-6H-purin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine

2.1: 4-methylmorpholine N-oxide / dichloromethane / 20 °C / Cooling with ice

3.1: dmap; triethylamine / dichloromethane / 20 °C / Cooling with ice

4.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / Inert atmosphere; Reflux

4.2: 0 °C / Inert atmosphere; Reflux

With dmap; N,O-bis-(trimethylsilyl)-acetamide; bromine; 4-methylmorpholine N-oxide; triethylamine; In dichloromethane;
DOI:10.1055/s-0032-1316916