3,5-diamino-6-chloropyrazine-2-carboxylic acid [(R)-4-{3-[4-((S)-2,3-dihydroxypropoxy)phenyl]propyl}imidazolidin-(2Z)-ylidene]amide

Base Information

Chemical Name:3,5-diamino-6-chloropyrazine-2-carboxylic acid [(R)-4-{3-[4-((S)-2,3-dihydroxypropoxy)phenyl]propyl}imidazolidin-(2Z)-ylidene]amide
CAS No.:1160939-59-2
Molecular Formula:C₂₀H₂₆ClN₇O₄
Molecular Weight:463.924
Hs Code.:

Synonyms:3,5-diamino-6-chloropyrazine-2-carboxylic acid [(R)-4-{3-[4-((S)-2,3-dihydroxypropoxy)phenyl]propyl}imidazolidin-(2Z)-ylidene]amide

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Chemical Property of 3,5-diamino-6-chloropyrazine-2-carboxylic acid [(R)-4-{3-[4-((S)-2,3-dihydroxypropoxy)phenyl]propyl}imidazolidin-(2Z)-ylidene]amide

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Technology Process of 3,5-diamino-6-chloropyrazine-2-carboxylic acid [(R)-4-{3-[4-((S)-2,3-dihydroxypropoxy)phenyl]propyl}imidazolidin-(2Z)-ylidene]amide

There total 6 articles about 3,5-diamino-6-chloropyrazine-2-carboxylic acid [(R)-4-{3-[4-((S)-2,3-dihydroxypropoxy)phenyl]propyl}imidazolidin-(2Z)-ylidene]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1160939-56-9
3,5-diamino-6-chloro-pyrazine-2-carboxylic acid [(R)-4-[3-(4-hydroxyphenyl)-propyl]imidazolidin-(2E)-ylidene]amide

: 60456-23-7
(S)-oxiranemethanol

: 1160939-59-2
3,5-diamino-6-chloropyrazine-2-carboxylic acid [(R)-4-{3-[4-((S)-2,3-dihydroxypropoxy)phenyl]propyl}imidazolidin-(2Z)-ylidene]amide

Guidance literature:: With potassium hydroxide; In 1,4-dioxane; at 50 ℃; for 78h;

Reference yield:

: 1160754-91-5
(R)-2-tert-butoxycarbonylamino-5-(4-tert-butoxyphenyl)-pentanoic acid ethyl ester

: 1160939-59-2
3,5-diamino-6-chloropyrazine-2-carboxylic acid [(R)-4-{3-[4-((S)-2,3-dihydroxypropoxy)phenyl]propyl}imidazolidin-(2Z)-ylidene]amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonia / methanol / 96 h / 20 °C

2.1: hydrogenchloride / diethyl ether / 72 h / 20 °C

3.1: 1H-imidazole / tetrahydrofuran / 4 h / 70 °C

4.1: diborane / tetrahydrofuran / 55.5 h / 5 - 35 °C

4.2: SCX-2 silica / 18 h

5.1: isopropyl alcohol / 36 h / 30 - 50 °C

6.1: potassium hydroxide / 1,4-dioxane / 78 h / 50 °C

With 1H-imidazole; hydrogenchloride; ammonia; potassium hydroxide; diborane; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; isopropyl alcohol;

Reference yield:

: 1160754-94-8
(R)-2-amino-5-[4-(tert-butyl-dimethylsilanyloxy)phenyl]-pentanoic acid amide

: 1160939-59-2
3,5-diamino-6-chloropyrazine-2-carboxylic acid [(R)-4-{3-[4-((S)-2,3-dihydroxypropoxy)phenyl]propyl}imidazolidin-(2Z)-ylidene]amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diborane / tetrahydrofuran / 55.5 h / 5 - 35 °C

1.2: SCX-2 silica / 18 h

2.1: isopropyl alcohol / 36 h / 30 - 50 °C

3.1: potassium hydroxide / 1,4-dioxane / 78 h / 50 °C

With potassium hydroxide; diborane; In tetrahydrofuran; 1,4-dioxane; isopropyl alcohol;