4-(tert-butyl-diphenyl-silanyloxymethyl)-1-(5-hydroxy-cyclooctyl)-3,3-dimethyl-pyrrolidin-2-one

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Chemical Name:4-(tert-butyl-diphenyl-silanyloxymethyl)-1-(5-hydroxy-cyclooctyl)-3,3-dimethyl-pyrrolidin-2-one
CAS No.:1057344-15-6
Molecular Formula:C₃₁H₄₅NO₃Si
Molecular Weight:507.789
Hs Code.:

Synonyms:4-(tert-butyl-diphenyl-silanyloxymethyl)-1-(5-hydroxy-cyclooctyl)-3,3-dimethyl-pyrrolidin-2-one

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Chemical Property of 4-(tert-butyl-diphenyl-silanyloxymethyl)-1-(5-hydroxy-cyclooctyl)-3,3-dimethyl-pyrrolidin-2-one

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Technology Process of 4-(tert-butyl-diphenyl-silanyloxymethyl)-1-(5-hydroxy-cyclooctyl)-3,3-dimethyl-pyrrolidin-2-one

There total 11 articles about 4-(tert-butyl-diphenyl-silanyloxymethyl)-1-(5-hydroxy-cyclooctyl)-3,3-dimethyl-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 910789-89-8
4-(tert-butyl-diphenyl-silanyloxy)-3-formyl-2,2-dimethyl-butyric acid methyl ester

: 90226-60-1
5-amino-cyclooctanol

: 1057344-15-6
4-(tert-butyl-diphenyl-silanyloxymethyl)-1-(5-hydroxy-cyclooctyl)-3,3-dimethyl-pyrrolidin-2-one

Guidance literature:: 4-(tert-butyl-diphenyl-silanyloxy)-3-formyl-2,2-dimethyl-butyric acid methyl ester; 5-amino-cyclooctanol; In tetrahydrofuran; at 20 ℃; for 5h; Molecular sieve;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 124770-00-9
1-(tert-butyldimethylsiloxy)cyclooctan-5-ol

: 1057344-15-6
4-(tert-butyl-diphenyl-silanyloxymethyl)-1-(5-hydroxy-cyclooctyl)-3,3-dimethyl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 3 h / 0 - 20 °C / Molecular sieve

2.1: ammonium acetate; sodium cyanoborohydride / methanol / 12 h

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 23 °C

5.1: hydrogen / palladium hydroxide on carbon / methanol / 2 h / 23 °C

6.1: tetrahydrofuran / 5 h / 20 °C / Molecular sieve

6.2: 20 °C

With tetrapropylammonium perruthennate; ammonium acetate; tetrabutyl ammonium fluoride; hydrogen; sodium cyanoborohydride; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; palladium hydroxide on carbon; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 124770-01-0
5-(tert-butyldimethylsilanyloxy)-cyclooctanone

: 1057344-15-6
4-(tert-butyl-diphenyl-silanyloxymethyl)-1-(5-hydroxy-cyclooctyl)-3,3-dimethyl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate; sodium cyanoborohydride / methanol / 12 h

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 23 °C

4.1: hydrogen / palladium hydroxide on carbon / methanol / 2 h / 23 °C

5.1: tetrahydrofuran / 5 h / 20 °C / Molecular sieve

5.2: 20 °C

With ammonium acetate; tetrabutyl ammonium fluoride; hydrogen; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; palladium hydroxide on carbon; In tetrahydrofuran; methanol; dichloromethane;