Atorvastatin EP IMpurity F

Base Information

• Chemical Name: Atorvastatin EP IMpurity F
• CAS No.: 887196-24-9
• Molecular Formula: C₄₀H₄₈FN₃O₈
• Molecular Weight: 717.835
• Mol file: 887196-24-9.mol

Synonyms:C₄₀H₄₈FN₃O₈

Chemical Property of Atorvastatin EP IMpurity F

Chemical Property:

• Boiling Point: 934.8±65.0 °C(Predicted)
• PKA: 4.30±0.10(Predicted)
• Density: 1.28±0.1 g/cm3(Predicted)

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Atorvastatin EP IMpurity F

There total 2 articles about Atorvastatin EP IMpurity F which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

calcium (3S,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxyheptanoate → 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid (581772-29-4) + C26H24FNO5 (887196-28-3) + 5'-deshydroxy atorvastatin (887196-27-2) + 3'-deshydroxy atorvastatin (887196-26-1) + 3-oxo atorvastatin (887196-30-7) + C33H35FN2O7 (887470-43-1) + C40H48FN3O8 (887196-24-9) + 2C33H35N2O5(1-)*Ca(2+)*3H2O + O-methyl atorvastatin calcium + lipitor (134523-03-8) + 3-<(4-fluorophenyl)carbonyl>-2-(2-methyl-1-oxopropyl)-N,3-diphenyl-2-oxiranecarboxamide (148146-51-4) + (3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate (345891-62-5)

Guidance literature:

With water; In tetrahydrofuran; cyclohexane; at 20 - 70 ℃; for 4.75h; Product distribution / selectivity; Molecular sieve;

Reference yield:

C47H60FN3O8 → C40H48FN3O8 (887196-24-9)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 25 ℃; for 6h;

DOI:10.1135/cccc20080229

Reference yield:

C40H48FN3O8 (887196-24-9) → calcium (3R,5R)-7-{(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxyheptanamido}-3,5-dihydroxyheptanoate

Guidance literature:

C₄₀H₄₈FN₃O₈; With sodium hydroxide; at 35 ℃; for 15h;

With calcium acetate; In ethyl acetate; Further stages.;

DOI:10.1135/cccc20080229

Refernces

• 1、 -. "Process for the production of atorvastatin calcium un amorphous form". Page/Page column 16. . Retrieved 2010/11/30.