Technology Process of (R*,S*)-4-(mesyloxy)-7-(p-toluenesulfonamido)decane
There total 6 articles about (R*,S*)-4-(mesyloxy)-7-(p-toluenesulfonamido)decane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
tetrahydrofuran;
1) 0 deg C, 1.5 h, 2) RT, 1 h;
DOI:10.1021/jo00290a010
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1) (i-Bu)2AlH, 2) CuCl / 1) hexane, 2) THF
2: 61 percent / LiCl, p-benzoquinone / Pd(OAc)2 / pentane; acetic acid / 28 h / Ambient temperature
3: 62 percent / Cs2CO3 / dimethylformamide / 48 h / 50 °C
4: 95 percent / aqueous NaOH / methanol / 0.75 h / Heating
5: 99.5 percent / H2 / PtO2 / methanol / 3 h / 3800 Torr / Ambient temperature
6: 90 percent / triethylamine / tetrahydrofuran / 1) 0 deg C, 1.5 h, 2) RT, 1 h
With
sodium hydroxide; hydrogen; diisobutylaluminium hydride; caesium carbonate; triethylamine; p-benzoquinone; copper(l) chloride; lithium chloride;
platinum(IV) oxide; palladium diacetate;
In
tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide; pentane;
DOI:10.1021/jo00290a010
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 61 percent / LiCl, p-benzoquinone / Pd(OAc)2 / pentane; acetic acid / 28 h / Ambient temperature
2: 62 percent / Cs2CO3 / dimethylformamide / 48 h / 50 °C
3: 95 percent / aqueous NaOH / methanol / 0.75 h / Heating
4: 99.5 percent / H2 / PtO2 / methanol / 3 h / 3800 Torr / Ambient temperature
5: 90 percent / triethylamine / tetrahydrofuran / 1) 0 deg C, 1.5 h, 2) RT, 1 h
With
sodium hydroxide; hydrogen; caesium carbonate; triethylamine; p-benzoquinone; lithium chloride;
platinum(IV) oxide; palladium diacetate;
In
tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide; pentane;
DOI:10.1021/jo00290a010
