(2S,5S)-2,5-diisopropyl-1,4-bis(3-phenylpropanoyl)piperazine

Base Information

• Chemical Name: (2S,5S)-2,5-diisopropyl-1,4-bis(3-phenylpropanoyl)piperazine
• CAS No.: 114409-86-8
• Molecular Formula: C₂₈H₃₈N₂O₂
• Molecular Weight: 434.622
• Mol file: 114409-86-8.mol

Synonyms:(2S,5S)-2,5-diisopropyl-1,4-bis(3-phenylpropanoyl)piperazine

Chemical Property of (2S,5S)-2,5-diisopropyl-1,4-bis(3-phenylpropanoyl)piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,5S)-2,5-diisopropyl-1,4-bis(3-phenylpropanoyl)piperazine

There total 2 articles about (2S,5S)-2,5-diisopropyl-1,4-bis(3-phenylpropanoyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2S,5S)-2,5-bis(isopropyl)piperazine (114409-91-5,114420-45-0) + hydrocinnamic acid chloride (645-45-4) → (2S,5S)-2,5-diisopropyl-1,4-bis(3-phenylpropanoyl)piperazine (114409-86-8)

Guidance literature:

With triethylamine; In dichloromethane; for 13h;

DOI:10.1246/bcsj.60.3450

Reference yield:

(3S,6S)-3,6-bis(isopropyl)piperazine-2,5-dione (19943-16-9) → (2S,5S)-2,5-diisopropyl-1,4-bis(3-phenylpropanoyl)piperazine (114409-86-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / sodium borohydride-titanium tetrachloride

2: 95 percent / triethylamine / CH₂Cl₂ / 13 h

With sodium tetrahydroborate; titanium tetrachloride; triethylamine; In dichloromethane;

DOI:10.1246/bcsj.60.3450

Reference yield:

(2S,5S)-2,5-diisopropyl-1,4-bis(3-phenylpropanoyl)piperazine (114409-86-8) + methyl iodide (74-88-4) → (S)-1-[(2S,5S)-2,5-Diisopropyl-4-((S)-2-methyl-3-phenyl-propionyl)-piperazin-1-yl]-2-methyl-3-phenyl-propan-1-one

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -30 deg C, 30 min; 2.) -78 deg C, 3 h;

DOI:10.1246/bcsj.60.3450

upstream raw materials:

(2S,5S)-2,5-bis(isopropyl)piperazine

hydrocinnamic acid chloride

(3S,6S)-3,6-bis(isopropyl)piperazine-2,5-dione