2-acetamido-3,6-di-O-benzyl-1-O-tert-butyldimethylsilyl-2-deoxy-4-O-methyl-β-D-glucopyranose

Base Information

Chemical Name:2-acetamido-3,6-di-O-benzyl-1-O-tert-butyldimethylsilyl-2-deoxy-4-O-methyl-β-D-glucopyranose
CAS No.:732247-09-5
Molecular Formula:C₂₉H₄₃NO₆Si
Molecular Weight:529.749
Hs Code.:

Synonyms:2-acetamido-3,6-di-O-benzyl-1-O-tert-butyldimethylsilyl-2-deoxy-4-O-methyl-β-D-glucopyranose

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Chemical Property of 2-acetamido-3,6-di-O-benzyl-1-O-tert-butyldimethylsilyl-2-deoxy-4-O-methyl-β-D-glucopyranose

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Technology Process of 2-acetamido-3,6-di-O-benzyl-1-O-tert-butyldimethylsilyl-2-deoxy-4-O-methyl-β-D-glucopyranose

There total 3 articles about 2-acetamido-3,6-di-O-benzyl-1-O-tert-butyldimethylsilyl-2-deoxy-4-O-methyl-β-D-glucopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 108-24-7
acetic anhydride

: 732247-03-9
3,6-di-O-benzyl-1-O-tert-butyldimethylsilyl-2-deoxy-4-O-methyl-2-phthalimido-β-D-glucopyranose

: 732247-09-5
2-acetamido-3,6-di-O-benzyl-1-O-tert-butyldimethylsilyl-2-deoxy-4-O-methyl-β-D-glucopyranose

Guidance literature:: 3,6-di-O-benzyl-1-O-tert-butyldimethylsilyl-2-deoxy-4-O-methyl-2-phthalimido-β-D-glucopyranose; With hydrazine; In methanol; at 55 ℃; for 24h;

acetic anhydride; In pyridine;
DOI:10.1016/j.carres.2004.03.014

Reference yield:

: 100-39-0
benzyl bromide

: 732247-09-5
2-acetamido-3,6-di-O-benzyl-1-O-tert-butyldimethylsilyl-2-deoxy-4-O-methyl-β-D-glucopyranose

Guidance literature:: Multi-step reaction with 3 steps

1.1: 71 percent / dibutyltin oxide; TBAI / toluene / Heating

2.1: 59 percent / NaH / dimethylformamide / 72 h / 0 - 20 °C

3.1: hydrazine / methanol / 24 h / 55 °C

3.2: 79 percent / pyridine

With tetra-(n-butyl)ammonium iodide; sodium hydride; di(n-butyl)tin oxide; hydrazine; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.carres.2004.03.014

Reference yield:

: 732246-93-4
(tert-butyl)dimethylsilyl 2-deoxy-2-phthalimido-β-D-glucopyranoside

: 732247-09-5
2-acetamido-3,6-di-O-benzyl-1-O-tert-butyldimethylsilyl-2-deoxy-4-O-methyl-β-D-glucopyranose

Guidance literature:: Multi-step reaction with 3 steps

1.1: 71 percent / dibutyltin oxide; TBAI / toluene / Heating

2.1: 59 percent / NaH / dimethylformamide / 72 h / 0 - 20 °C

3.1: hydrazine / methanol / 24 h / 55 °C

3.2: 79 percent / pyridine

With tetra-(n-butyl)ammonium iodide; sodium hydride; di(n-butyl)tin oxide; hydrazine; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.carres.2004.03.014