(R)-4-(1-AMINOETHYL)PHENOL

Base Information

• Chemical Name: (R)-4-(1-AMINOETHYL)PHENOL
• CAS No.: 221670-72-0
• Molecular Formula: C8H11 N O
• Molecular Weight: 137.181
• Mol file: 221670-72-0.mol

Synonyms:4-[(1R)-1-AMINOETHYL]PHENOL;(R)-4-(1-AMINOETHYL)PHENOL;Phenol, 4-[(1S)-1-aminoethyl]- (9CI);Phenol, 4-[(1S)-1-aminoethyl]-

Chemical Property of (R)-4-(1-AMINOETHYL)PHENOL

Chemical Property:

• Boiling Point: 252.2±15.0 °C(Predicted)
• PKA: 10.20±0.26(Predicted)
• PSA: 46.25000
• Density: 1.096±0.06 g/cm3(Predicted)
• LogP: 2.11220

Purity/Quality:

99% ^*data from raw suppliers

4-[(1S)-1-Aminoethyl]phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-4-(1-Aminoethyl)phenol is used as an intermediate in organic synthesis.

Technology Process of (R)-4-(1-AMINOETHYL)PHENOL

There total 5 articles about (R)-4-(1-AMINOETHYL)PHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(S)-1-(4-tert-butoxyphenyl)ethylamine sulfate (917911-59-2) → (S)-4-(1-amino-ethyl)-phenol (221670-72-0)

Guidance literature:

(S)-1-(4-tert-butoxyphenyl)ethylamine sulfate; With sulfuric acid; water; at 85 ℃; for 3h; pH=1;

With sodium hydroxide; water; pH=10.2;

Reference yield:

α-methyl-p-hydroxybenzylamine (134855-87-1) → (S)-4-(1-amino-ethyl)-phenol (221670-72-0) + 4-Hydroxyacetophenone (99-93-4)

Guidance literature:

With (R)-amine dehydrogenase; In dimethyl sulfoxide; at 37 ℃; pH=8.5; enantioselective reaction; Catalytic behavior; Resolution of racemate; Microbiological reaction; Enzymatic reaction;

DOI:10.1002/cctc.201900080

Reference yield:

(S)-1-(4-methoxyphenyl)ethylamine (6298-96-0,22038-86-4,35600-82-9,41851-59-6) → (S)-4-(1-amino-ethyl)-phenol (221670-72-0)

Guidance literature:

(S)-1-(4-methoxyphenyl)ethylamine; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 4h;

With water; sodium carbonate; In dichloromethane; at 0 ℃; pH=8;

upstream raw materials:

(S)-1-(4-tert-butoxyphenyl)ethylamine sulfate

(S)-1-(4-methoxyphenyl)ethylamine

α-methyl-p-hydroxybenzylamine

Downstream raw materials:

(S)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate

C₂₂H₃₀N₂O₄

(R)-tert-butyl 3-(4-((S)-1-(benzyloxycarbonylamino)ethyl)phenoxy)pyrrolidine-1-carboxylate

benzyl N-[(1S)-1-(4-hydroxyphenyl)ethyl]carbamate