(R)-tert-butyl 3-(4-((S)-1-(benzyloxycarbonylamino)ethyl)phenoxy)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 3-(4-((S)-1-(benzyloxycarbonylamino)ethyl)phenoxy)pyrrolidine-1-carboxylate
• CAS No.: 1620690-56-3
• Molecular Formula: C₂₅H₃₂N₂O₅
• Molecular Weight: 440.539
• Mol file: 1620690-56-3.mol

Synonyms:(R)-tert-butyl 3-(4-((S)-1-(benzyloxycarbonylamino)ethyl)phenoxy)pyrrolidine-1-carboxylate

Chemical Property of (R)-tert-butyl 3-(4-((S)-1-(benzyloxycarbonylamino)ethyl)phenoxy)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 3-(4-((S)-1-(benzyloxycarbonylamino)ethyl)phenoxy)pyrrolidine-1-carboxylate

There total 6 articles about (R)-tert-butyl 3-(4-((S)-1-(benzyloxycarbonylamino)ethyl)phenoxy)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl N-[(1S)-1-(4-hydroxyphenyl)ethyl]carbamate (645391-89-5) + (S)-tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate (132945-75-6) → (R)-tert-butyl 3-(4-((S)-1-(benzyloxycarbonylamino)ethyl)phenoxy)pyrrolidine-1-carboxylate (1620690-56-3)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

benzyl N-[(1S)-1-(4-hydroxyphenyl)ethyl]carbamate (645391-89-5) + 3-methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester (141699-57-2) → (R)-tert-butyl 3-(4-((S)-1-(benzyloxycarbonylamino)ethyl)phenoxy)pyrrolidine-1-carboxylate (1620690-56-3)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

(S)-1-(4-methoxyphenyl)ethylamine (6298-96-0,22038-86-4,35600-82-9,41851-59-6) → (R)-tert-butyl 3-(4-((S)-1-(benzyloxycarbonylamino)ethyl)phenoxy)pyrrolidine-1-carboxylate (1620690-56-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen bromide / acetic acid / 4 h / 100 °C

2: sodium hydrogencarbonate / tetrahydrofuran; water / 3 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 80 °C

With hydrogen bromide; sodium hydrogencarbonate; caesium carbonate; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

(S)-1-(4-methoxyphenyl)ethylamine

benzyl N-[(1S)-1-(4-hydroxyphenyl)ethyl]carbamate

3-methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester

(S)-4-(1-amino-ethyl)-phenol hydrobromid