5-fluoro-2-(((3R,6R)-1-(2-iodo-5-methyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)pyridine

Base Information

Chemical Name:5-fluoro-2-(((3R,6R)-1-(2-iodo-5-methyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)pyridine
CAS No.:1088993-96-7
Molecular Formula:C₂₀H₂₂FIN₂O₂
Molecular Weight:468.31
Hs Code.:

Synonyms:5-fluoro-2-(((3R,6R)-1-(2-iodo-5-methyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)pyridine

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Chemical Property of 5-fluoro-2-(((3R,6R)-1-(2-iodo-5-methyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)pyridine

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Technology Process of 5-fluoro-2-(((3R,6R)-1-(2-iodo-5-methyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)pyridine

There total 12 articles about 5-fluoro-2-(((3R,6R)-1-(2-iodo-5-methyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1104546-96-4
5-methyl-2-(2Η-1,2,3-triazol-2-yl)benzoyl chloride

: 1088993-93-4
5-fluoro-2-((3R,6R)-6-methyl-piperidin-3-ylmethoxy)pyridine

: 1088993-96-7
5-fluoro-2-(((3R,6R)-1-(2-iodo-5-methyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)pyridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 278789-37-0
(6-methyl-piperidin-3-yl)methanol

: 1088993-96-7
5-fluoro-2-(((3R,6R)-1-(2-iodo-5-methyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 22 °C

2: ethanol; hexane / Resolution of racemate

3: PS-triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane

4: hydrogen / 10 % Pd(OH)2/C / ethanol / 0.67 h / 22 °C / 760.05 Torr

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

With PS-triphenylphosphine; di-isopropyl azodicarboxylate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; 10 % Pd(OH)2/C; In ethanol; hexane; dichloromethane;

Reference yield:

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: 1088993-96-7
5-fluoro-2-(((3R,6R)-1-(2-iodo-5-methyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;