2-(2-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methyl-piperidin-1-yl)carbonyl)-4-methylphenyl)pyrazine

Base Information

Chemical Name:2-(2-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methyl-piperidin-1-yl)carbonyl)-4-methylphenyl)pyrazine
CAS No.:1088991-71-2
Molecular Formula:C₂₄H₂₅FN₄O₂
Molecular Weight:420.487
Hs Code.:

Synonyms:2-(2-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methyl-piperidin-1-yl)carbonyl)-4-methylphenyl)pyrazine

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Chemical Property of 2-(2-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methyl-piperidin-1-yl)carbonyl)-4-methylphenyl)pyrazine

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Technology Process of 2-(2-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methyl-piperidin-1-yl)carbonyl)-4-methylphenyl)pyrazine

There total 14 articles about 2-(2-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methyl-piperidin-1-yl)carbonyl)-4-methylphenyl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1088993-96-7
5-fluoro-2-(((3R,6R)-1-(2-iodo-5-methyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)pyridine

: (2-pyrazinyl)tributyltin

: 1088991-71-2
2-(2-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methyl-piperidin-1-yl)carbonyl)-4-methylphenyl)pyrazine

Guidance literature:: With copper(l) iodide; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 278789-37-0
(6-methyl-piperidin-3-yl)methanol

: 1088991-71-2
2-(2-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methyl-piperidin-1-yl)carbonyl)-4-methylphenyl)pyrazine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 22 °C

2: ethanol; hexane / Resolution of racemate

3: PS-triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane

4: hydrogen / 10 % Pd(OH)2/C / ethanol / 0.67 h / 22 °C / 760.05 Torr

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

6: copper(l) iodide; cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C

With copper(l) iodide; PS-triphenylphosphine; di-isopropyl azodicarboxylate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 % Pd(OH)2/C; In ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: 1088991-71-2
2-(2-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methyl-piperidin-1-yl)carbonyl)-4-methylphenyl)pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

3: copper(l) iodide; cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C

With copper(l) iodide; thionyl chloride; N-ethyl-N,N-diisopropylamine; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;