3-fluoro-4-[7-methoxy-3-methyl-2-oxo-8-(2-thiophen-3-ylethyl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]benzonitrile

Base Information

Chemical Name:3-fluoro-4-[7-methoxy-3-methyl-2-oxo-8-(2-thiophen-3-ylethyl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]benzonitrile
CAS No.:1360628-87-0
Molecular Formula:C₂₅H₁₉FN₄O₂S
Molecular Weight:458.516
Hs Code.:

Synonyms:3-fluoro-4-[7-methoxy-3-methyl-2-oxo-8-(2-thiophen-3-ylethyl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]benzonitrile

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Chemical Property of 3-fluoro-4-[7-methoxy-3-methyl-2-oxo-8-(2-thiophen-3-ylethyl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]benzonitrile

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Technology Process of 3-fluoro-4-[7-methoxy-3-methyl-2-oxo-8-(2-thiophen-3-ylethyl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]benzonitrile

There total 9 articles about 3-fluoro-4-[7-methoxy-3-methyl-2-oxo-8-(2-thiophen-3-ylethyl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360628-86-9
3-fluoro-4-{7-methoxy-3-methyl-2-oxo-8-[(E)-2-thiophen-3-ylvinyl]-2,3-dihydroimidazo[4,5-c]quinolin-1-yl}benzonitrile

: 1360628-87-0
3-fluoro-4-[7-methoxy-3-methyl-2-oxo-8-(2-thiophen-3-ylethyl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]benzonitrile

Guidance literature:: With palladium 10% on activated carbon; In ethanol;

Reference yield:

: 1360628-62-1
4-(8-benzyloxy-7-methoxy-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-3-fluorobenzonitrile

: 1360628-87-0
3-fluoro-4-[7-methoxy-3-methyl-2-oxo-8-(2-thiophen-3-ylethyl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: boron tribromide; trifluoroacetic acid / dichloromethane / 0.5 h / Inert atmosphere; Cooling with ice

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3: (bis(tricyclohexyl)phosphine)palladium(II) dichloride; potassium phosphate / N,N-dimethyl-formamide / 0.75 h / 130 °C / Microwave irradiation

4: palladium 10% on activated carbon / ethanol

With potassium phosphate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; palladium 10% on activated carbon; boron tribromide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1360628-57-4
3-fluoro-4-(8-hydroxy-7-methoxy-3-methyl-2-oxo-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)benzonitrile

: 1360628-87-0
3-fluoro-4-[7-methoxy-3-methyl-2-oxo-8-(2-thiophen-3-ylethyl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2: (bis(tricyclohexyl)phosphine)palladium(II) dichloride; potassium phosphate / N,N-dimethyl-formamide / 0.75 h / 130 °C / Microwave irradiation

3: palladium 10% on activated carbon / ethanol

With potassium phosphate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; palladium 10% on activated carbon; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;