[1-(4-cyano-2-fluorophenyl)-7-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]trifluoromethanesulfonate

Base Information

Chemical Name:[1-(4-cyano-2-fluorophenyl)-7-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]trifluoromethanesulfonate
CAS No.:1360629-01-1
Molecular Formula:C₂₀H₁₂F₄N₄O₅S
Molecular Weight:496.399
Hs Code.:

Synonyms:[1-(4-cyano-2-fluorophenyl)-7-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]trifluoromethanesulfonate

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Chemical Property of [1-(4-cyano-2-fluorophenyl)-7-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]trifluoromethanesulfonate

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Technology Process of [1-(4-cyano-2-fluorophenyl)-7-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]trifluoromethanesulfonate

There total 6 articles about [1-(4-cyano-2-fluorophenyl)-7-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360628-62-1
4-(8-benzyloxy-7-methoxy-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-3-fluorobenzonitrile

: 1360629-01-1
[1-(4-cyano-2-fluorophenyl)-7-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide; trifluoroacetic acid / dichloromethane / 0.5 h / Inert atmosphere; Cooling with ice

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

With boron tribromide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1360628-98-3
4-(6-benzyloxy-7-methoxy-3-nitro-quinolin-4-yl-amino)-3-fluorobenzonitrile

: 1360629-01-1
[1-(4-cyano-2-fluorophenyl)-7-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: tin(II) chloride dihdyrate / ethanol / 0.5 h / 70 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

3: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

4: boron tribromide; trifluoroacetic acid / dichloromethane / 0.5 h / Inert atmosphere; Cooling with ice

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

With tin(II) chloride dihdyrate; boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1360628-61-0
4-(8-benzyloxy-7-methoxy-2-oxo-2,3-dihydroimidazo-[4,5-c]quinolin-1-yl)-3-fluorobenzonitrile

: 1360629-01-1
[1-(4-cyano-2-fluorophenyl)-7-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2: boron tribromide; trifluoroacetic acid / dichloromethane / 0.5 h / Inert atmosphere; Cooling with ice

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

With boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;