7-benzylidene-4-phenyl-3-cyano-2-thioxo-2,5,6,7-tetrahydro-1H-pyrindines

Base Information

• Chemical Name: 7-benzylidene-4-phenyl-3-cyano-2-thioxo-2,5,6,7-tetrahydro-1H-pyrindines
• CAS No.: 108223-13-8
• Molecular Formula: C₂₂H₁₆N₂S
• Molecular Weight: 340.448
• Mol file: 108223-13-8.mol

Synonyms:7-benzylidene-4-phenyl-3-cyano-2-thioxo-2,5,6,7-tetrahydro-1H-pyrindines

Chemical Property of 7-benzylidene-4-phenyl-3-cyano-2-thioxo-2,5,6,7-tetrahydro-1H-pyrindines

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-benzylidene-4-phenyl-3-cyano-2-thioxo-2,5,6,7-tetrahydro-1H-pyrindines

There total 8 articles about 7-benzylidene-4-phenyl-3-cyano-2-thioxo-2,5,6,7-tetrahydro-1H-pyrindines which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Cyanothioacetamide (7357-70-2) + 2,5-dibenzylidenecyclopentanone (895-80-7) → 7-benzylidene-4-phenyl-3-cyano-2-thioxo-2,5,6,7-tetrahydro-1H-pyrindines (108223-13-8)

Guidance literature:

With sodium ethanolate; In ethanol; for 4h; Heating;

Reference yield: 42.0%

cyclopentanone (120-92-3) + (E)-2-cyano-3-phenylprop-2-enethioamide (68029-52-7) → 4-phenyl-2-thioxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carbonitrile (83236-48-0) + 7-benzylidene-4-phenyl-3-cyano-2-thioxo-2,5,6,7-tetrahydro-1H-pyrindines (108223-13-8)

Guidance literature:

With piperidine; In ethanol; for 3h; Heating;

Reference yield:

cyclopentanone (120-92-3) → 7-benzylidene-4-phenyl-3-cyano-2-thioxo-2,5,6,7-tetrahydro-1H-pyrindines (108223-13-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: piperidine / ethanol / 3 h / Heating

1.2: Et₃N / ethanol / 2 h / Heating

2.1: NaOEt / ethanol / 1 h / Heating

3.1: piperidine / dioxane / 3 h / Heating

With piperidine; sodium ethanolate; In 1,4-dioxane; ethanol;

upstream raw materials:

Cyanothioacetamide

2,5-dibenzylidenecyclopentanone

4-phenyl-2-thioxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carbonitrile

benzaldehyde

Downstream raw materials:

C₂₄H₁₉N₃OS

C₂₄H₁₇N₃S

7-benzylidene-4-phenyl-3-cyano-5,6-dihydro-7H-2-pyrindinylthioacetic acid

C₃₀H₂₂N₂OS

Refernces

• 1、 Shestopalov, A. M.,Sharanin, Yu. A.. "CYCLIZATION OF NITRILES. XIX. SYNTHESIS AND REACTION OF THE DERIVATIVES OF 2-OXO- AND 2-THIOXO-2,5,6,7-TETRAHYDRO-1H-PYRINDINES". . p. 1163 - 1168. Retrieved 2007/10/02.