n-butyl 4-((2-[(2R)-2-((1E,3S)-4-(3-pyridin-2-ylphenyl)-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)butanoate

Base Information

Chemical Name:n-butyl 4-((2-[(2R)-2-((1E,3S)-4-(3-pyridin-2-ylphenyl)-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)butanoate
CAS No.:1380347-41-0
Molecular Formula:C₂₉H₃₈N₂O₄S
Molecular Weight:510.698
Hs Code.:

Synonyms:n-butyl 4-((2-[(2R)-2-((1E,3S)-4-(3-pyridin-2-ylphenyl)-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)butanoate

Suppliers and Price of n-butyl 4-((2-[(2R)-2-((1E,3S)-4-(3-pyridin-2-ylphenyl)-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)butanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of n-butyl 4-((2-[(2R)-2-((1E,3S)-4-(3-pyridin-2-ylphenyl)-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)butanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of n-butyl 4-((2-[(2R)-2-((1E,3S)-4-(3-pyridin-2-ylphenyl)-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)butanoate

There total 5 articles about n-butyl 4-((2-[(2R)-2-((1E,3S)-4-(3-pyridin-2-ylphenyl)-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₆N₂O₄S

: 1380347-41-0
n-butyl 4-((2-[(2R)-2-((1E,3S)-4-(3-pyridin-2-ylphenyl)-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)butanoate

Guidance literature:: C₂₉H₃₆N₂O₄S; With borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at 20 ℃; for 1.08333h; Inert atmosphere;

With methanol; In tetrahydrofuran; toluene; at 20 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.04.008

Reference yield:

: 621-37-4
m-hydroxyphenylacetic acid

: 1380347-41-0
n-butyl 4-((2-[(2R)-2-((1E,3S)-4-(3-pyridin-2-ylphenyl)-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)butanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / acetonitrile / 18 h / 80 °C / Inert atmosphere

4.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

5.1: n-butyllithium / hexane; toluene / 1 h / -78 °C / Inert atmosphere

5.2: 2 h / -78 °C / Inert atmosphere

6.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere

6.2: 2 h / 0 °C / Inert atmosphere

7.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 1.08 h / 20 °C / Inert atmosphere

7.2: 0.08 h / 20 °C / Inert atmosphere

With pyridine; potassium phosphate; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; borane-THF; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; toluene; acetonitrile; mineral oil; 4.1: Suzuki coupling / 6.1: Horner-Wadsworth-Emmons olefination / 6.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.bmc.2012.04.008

Reference yield:

: 1365393-21-0
butyl 4-({2-[(2R)-2-formyl-5-oxo-1-pyrrolidinyl]ethyl}thio)butanoate

: 1380347-41-0
n-butyl 4-((2-[(2R)-2-((1E,3S)-4-(3-pyridin-2-ylphenyl)-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 0 °C / Inert atmosphere

2.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 1.08 h / 20 °C / Inert atmosphere

2.2: 0.08 h / 20 °C / Inert atmosphere

With borane-THF; sodium hydride; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; mineral oil; 1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.bmc.2012.04.008