Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI)

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI)
• CAS No.: 681807-60-3
• Molecular Formula: C8H13 N O2 . Cl H
• Molecular Weight: 191.658
• Mol file: 681807-60-3.mol

Synonyms:Cyclopropanecarboxylicacid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI)

Chemical Property of Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI)

Chemical Property:

• PSA: 52.32000
• LogP: 1.95520

Purity/Quality:

≥95% ^*data from raw suppliers

Cyclopropanecarboxylicacid,1-amino-2-ethenyl-,ethylester,(Hydrochloride)(9CI) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI)

There total 5 articles about Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1R,2S)-ethyl 1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylate (681807-59-0,213316-49-5) → (1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride (681807-60-3,259214-54-5,259214-56-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

C15H17NO2 → (1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride (681807-60-3,259214-54-5,259214-56-7)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 2h;

Reference yield:

(1S,2R)-1-(N-phenylmethylene)amino-2-vinylcyclopropanecarboxylic acid ethyl ester (1269195-07-4) → (1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride (681807-60-3,259214-54-5,259214-56-7)

Guidance literature:

(1S,2R)-1-(N-phenylmethylene)amino-2-vinylcyclopropanecarboxylic acid ethyl ester; With water; In tert-butyl methyl ether;

With hydrogenchloride; In water; at 20 ℃; for 2h;

With sodium hydroxide; In tert-butyl methyl ether; water; at 0 ℃; pH=14;

upstream raw materials:

(1S,2R)-1-(N-phenylmethylene)amino-2-vinylcyclopropanecarboxylic acid ethyl ester

(1R,2S)/(1S,2R) 1-amino-2-vinylcyclopropane carboxylic acid ethyl ester

(1R,2S)-ethyl 1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylate

C₂₁H₂₁NO₂

Downstream raw materials:

(1R,2S)-ethyl 1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylate

(1RS,2SR)-ethyl 2-vinyl-1-(tert-butoxycarbonylamino)cyclopropanecarboxylate

(2S,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,4R)-2-((1S,2R)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester