6-chloro-4-ethoxy-2-methyl-3-(6-(4-(trifluoromethoxy)phenoxy)pyridin-3-yl)quinolin

Base Information

Chemical Name:6-chloro-4-ethoxy-2-methyl-3-(6-(4-(trifluoromethoxy)phenoxy)pyridin-3-yl)quinolin
CAS No.:1599467-86-3
Molecular Formula:C₂₄H₁₈ClF₃N₂O₃
Molecular Weight:474.867
Hs Code.:

Synonyms:6-chloro-4-ethoxy-2-methyl-3-(6-(4-(trifluoromethoxy)phenoxy)pyridin-3-yl)quinolin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-chloro-4-ethoxy-2-methyl-3-(6-(4-(trifluoromethoxy)phenoxy)pyridin-3-yl)quinolin

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Technology Process of 6-chloro-4-ethoxy-2-methyl-3-(6-(4-(trifluoromethoxy)phenoxy)pyridin-3-yl)quinolin

There total 8 articles about 6-chloro-4-ethoxy-2-methyl-3-(6-(4-(trifluoromethoxy)phenoxy)pyridin-3-yl)quinolin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1599467-58-9
6-chloro-4-ethoxy-3-iodo-2-methylquinoline

: 1599467-79-4
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(4-(trifluoromethoxy)phenoxy)pyridine

: 1599467-86-3
6-chloro-4-ethoxy-2-methyl-3-(6-(4-(trifluoromethoxy)phenoxy)pyridin-3-yl)quinolin

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; N,N-dimethyl-formamide; at 85 ℃; for 18h;
DOI:10.1021/jm500147k

Reference yield:

: 83842-54-0
HEI 713

: 1599467-86-3
6-chloro-4-ethoxy-2-methyl-3-(6-(4-(trifluoromethoxy)phenoxy)pyridin-3-yl)quinolin

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; potassium iodide; N-butylamine / water; N,N-dimethyl-formamide / 12 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

2.2: 8 h / 50 °C

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 85 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; potassium carbonate; N-butylamine; potassium iodide; In water; N,N-dimethyl-formamide; 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500147k

Reference yield:

: 187386-90-9
C₁₂H₁₄ClNO₂

: 1599467-86-3
6-chloro-4-ethoxy-2-methyl-3-(6-(4-(trifluoromethoxy)phenoxy)pyridin-3-yl)quinolin

Guidance literature:: Multi-step reaction with 4 steps

1.1: dowtherm A / 0.33 h / 250 °C

2.1: iodine; potassium iodide; N-butylamine / water; N,N-dimethyl-formamide / 12 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

3.2: 8 h / 50 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 85 °C

With dowtherm A; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; potassium carbonate; N-butylamine; potassium iodide; In water; N,N-dimethyl-formamide; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500147k