17-(cyclopropylmethyl)-4,5α-epoxy-3,6β-dihydroxy-6,14-endoethenomorphinan-7α-(N-phenethyl)carboxamide

Base Information

Chemical Name:17-(cyclopropylmethyl)-4,5α-epoxy-3,6β-dihydroxy-6,14-endoethenomorphinan-7α-(N-phenethyl)carboxamide
CAS No.:214064-41-2
Molecular Formula:C₃₁H₃₄N₂O₄
Molecular Weight:498.622
Hs Code.:

Synonyms:17-(cyclopropylmethyl)-4,5α-epoxy-3,6β-dihydroxy-6,14-endoethenomorphinan-7α-(N-phenethyl)carboxamide

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Chemical Property of 17-(cyclopropylmethyl)-4,5α-epoxy-3,6β-dihydroxy-6,14-endoethenomorphinan-7α-(N-phenethyl)carboxamide

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Technology Process of 17-(cyclopropylmethyl)-4,5α-epoxy-3,6β-dihydroxy-6,14-endoethenomorphinan-7α-(N-phenethyl)carboxamide

There total 7 articles about 17-(cyclopropylmethyl)-4,5α-epoxy-3,6β-dihydroxy-6,14-endoethenomorphinan-7α-(N-phenethyl)carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 214064-56-9
C₃₃H₃₈N₂O₄

: 214064-41-2
17-(cyclopropylmethyl)-4,5α-epoxy-3,6β-dihydroxy-6,14-endoethenomorphinan-7α-(N-phenethyl)carboxamide

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2004.05.024

Reference yield: 26.0%

: 51357-96-1
N-(2-phenylethyl)acrylamide

: 5083-80-7
N-(cyclopropylmethyl)northebaine

: 214064-41-2
17-(cyclopropylmethyl)-4,5α-epoxy-3,6β-dihydroxy-6,14-endoethenomorphinan-7α-(N-phenethyl)carboxamide

: C₃₁H₃₄N₂O₄

Guidance literature:: N-(2-phenylethyl)acrylamide; N-(cyclopropylmethyl)northebaine; for 20h; Heating;

With boron tribromide; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2004.05.024

Reference yield:

: 5083-80-7
N-(cyclopropylmethyl)northebaine

: 214064-41-2
17-(cyclopropylmethyl)-4,5α-epoxy-3,6β-dihydroxy-6,14-endoethenomorphinan-7α-(N-phenethyl)carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / 15 h / Heating

2: 76 percent / HCl / Heating

3: oxalyl chloride / CHCl₃ / 2 h / Heating

4: 100 percent / triethylamine / CHCl₃ / 1 h / 20 °C

5: 69 percent / BBr₃ / CH₂Cl₂ / 1 h / 20 °C

With hydrogenchloride; oxalyl dichloride; boron tribromide; triethylamine; In dichloromethane; chloroform; 1: Diels-Alder reaction;
DOI:10.1016/j.bmc.2004.05.024