methyl 7-fluoro-5-{4-fluoro-2-[(R)-1-(2,2,2-trifluoro-acetyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Base Information

Chemical Name:methyl 7-fluoro-5-{4-fluoro-2-[(R)-1-(2,2,2-trifluoro-acetyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate
CAS No.:1609122-84-0
Molecular Formula:C₂₅H₂₃F₅N₂O₆S
Molecular Weight:574.525
Hs Code.:

methyl 7-fluoro-5-{4-fluoro-2-[(R)-1-(2,2,2-trifluoro-acetyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Synonyms:methyl 7-fluoro-5-{4-fluoro-2-[(R)-1-(2,2,2-trifluoro-acetyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Chemical Property of methyl 7-fluoro-5-{4-fluoro-2-[(R)-1-(2,2,2-trifluoro-acetyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Technology Process of methyl 7-fluoro-5-{4-fluoro-2-[(R)-1-(2,2,2-trifluoro-acetyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

There total 15 articles about methyl 7-fluoro-5-{4-fluoro-2-[(R)-1-(2,2,2-trifluoro-acetyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609122-73-7
methyl 5-amino-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609122-85-1
4-fluoro-2-[(R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-3-ylmethyl]benzenesulfonyl chloride

: 1609122-84-0
methyl 7-fluoro-5-{4-fluoro-2-[(R)-1-(2,2,2-trifluoro-acetyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 1609122-76-0
methyl 7-(2,2-dimethylpropionylamino)-5-fluoro-2H-chromene-8-carboxylate

: 1609122-84-0
methyl 7-fluoro-5-{4-fluoro-2-[(R)-1-(2,2,2-trifluoro-acetyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water; dichloromethane / 2 h / 50 °C

2.1: sulfuric acid; methanol / 24 h / Reflux

2.2: 24 h / Reflux

3.1: zinc; ammonium chloride / 20 h / 85 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 72 h / 20 °C

With pyridine; methanol; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; ammonium chloride; sodium hydroxide; zinc; In dichloromethane; water;

Reference yield:

: 1609122-74-8
methyl 5-amino-1,1-dibromo-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609122-84-0
methyl 7-fluoro-5-{4-fluoro-2-[(R)-1-(2,2,2-trifluoro-acetyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; ammonium chloride / 20 h / 85 °C / Inert atmosphere

2: pyridine / dichloromethane / 72 h / 20 °C

With pyridine; ammonium chloride; zinc; In dichloromethane;