({4-[bis-(5-fluoro-2,4-dihydroxy-phenyl)methyl](2-methoxyphenyl)}methoxycarbonylmethylamino)acetic acid methyl ester

Base Information

• Chemical Name: ({4-[bis-(5-fluoro-2,4-dihydroxy-phenyl)methyl](2-methoxyphenyl)}methoxycarbonylmethylamino)acetic acid methyl ester
• CAS No.: 869634-72-0
• Molecular Formula: C₂₆H₂₅F₂NO₉
• Molecular Weight: 533.483

Synonyms:({4-[bis-(5-fluoro-2,4-dihydroxy-phenyl)methyl](2-methoxyphenyl)}methoxycarbonylmethylamino)acetic acid methyl ester

Chemical Property of ({4-[bis-(5-fluoro-2,4-dihydroxy-phenyl)methyl](2-methoxyphenyl)}methoxycarbonylmethylamino)acetic acid methyl ester

Chemical Property:

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Technology Process of ({4-[bis-(5-fluoro-2,4-dihydroxy-phenyl)methyl](2-methoxyphenyl)}methoxycarbonylmethylamino)acetic acid methyl ester

There total 2 articles about ({4-[bis-(5-fluoro-2,4-dihydroxy-phenyl)methyl](2-methoxyphenyl)}methoxycarbonylmethylamino)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

[(4-formyl-2-methoxy-phenyl)(methoxycarbonylmethyl)amino]-acetic acid methyl ester (869634-71-9) + 4-fluororesorcinol (103068-41-3) → ({4-[bis-(5-fluoro-2,4-dihydroxy-phenyl)methyl](2-methoxyphenyl)}methoxycarbonylmethylamino)acetic acid methyl ester (869634-72-0)

Guidance literature:

With methanesulfonic acid; In diethyl ether; dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jo051243i

Reference yield:

[(methoxycarbonylmethyl)(2-methoxyphenyl)amino]-acetic acid methyl ester (869634-78-6) → ({4-[bis-(5-fluoro-2,4-dihydroxy-phenyl)methyl](2-methoxyphenyl)}methoxycarbonylmethylamino)acetic acid methyl ester (869634-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: POCl₃ / 0.17 h

1.2: 90 percent / 0.5 h / 100 °C

2.1: 81 percent / MeSO₃H / diethyl ether; CH₂Cl₂ / 2 h / 20 °C

With methanesulfonic acid; trichlorophosphate; In diethyl ether; dichloromethane;

DOI:10.1021/jo051243i

Reference yield: 70.0%

({4-[bis-(5-fluoro-2,4-dihydroxy-phenyl)methyl](2-methoxyphenyl)}methoxycarbonylmethylamino)acetic acid methyl ester (869634-72-0) → {[4-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-2-methoxy-phenyl]-methoxycarbonylmethyl-amino}-acetic acid methyl ester

Guidance literature:

With acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; at 20 ℃; for 0.25h;

DOI:10.1021/jo051243i

upstream raw materials:

[(4-formyl-2-methoxy-phenyl)(methoxycarbonylmethyl)amino]-acetic acid methyl ester

4-fluororesorcinol

[(methoxycarbonylmethyl)(2-methoxyphenyl)amino]-acetic acid methyl ester

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