103068-41-3

Basic information

• Product Name: 4-Fluoro-1,3-benzenediol
• Synonyms: 4-FLUORO-1,3-DIHYDROXYBENZENE;4-FLUORORESORCINOL;4-Fluoro-1,3-benzenediol;4-Fluorobenzene-1,3-diol;4-Fluoro-1,3-benzenediol, 4-Fluoro-1,3-dihydroxybenzene;2,4-dihydroxyfluorobenzene;4-Fluororesorcinol, 1,3-Dihydroxy-4-fluorobenzene;1-Fluoro-2,4-dihydroxybenzene
• CAS NO: 103068-41-3
• Molecular Formula: C₆H₅FO₂
• Molecular Weight: 128.1
• EINECS: 213-861-4
• Product Categories: Aromatics;Miscellaneous Reagents;Fluorine series
• Mol File: 103068-41-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 96-100°C
• Boiling Point: 240.8 °C at 760 mmHg
• Flash Point: 99.4 °C
• Appearance: Off-white crystal
• Density: 1.415 g/cm³
• Vapor Pressure: 0.00402mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: ?20°C
• Solubility: DMSO, Methanol
• PKA: 8.49±0.10(Predicted)
• CAS DataBase Reference: 4-Fluoro-1,3-benzenediol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-1,3-benzenediol(103068-41-3)
• EPA Substance Registry System: 4-Fluoro-1,3-benzenediol(103068-41-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-34-36/37/38-22
• Safety Statements: 26-36/37/39
• RIDADR: 1759
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 103068-41-3(Hazardous Substances Data)

Usage

Chemical Properties

4-Fluoro-1,3-benzenediol is Brown Solid

Uses

Different sources of media describe the Uses of 103068-41-3 differently. You can refer to the following data:
1. Reagent used in the preparation of fluorescent dyes and indicators.
2. 4-Fluoro-1,3-benzenediol is used in the preparation of fluorescent dyes and indicators.

InChI:InChI=1/C12H4F8N2/c13-3-1(4(14)8(18)11(21)7(3)17)2-5(15)9(19)12(22)10(20)6(2)16/h21-22H2

Upstream product

• 108-46-3 recorcinol 
• 151-10-0 1,3-Dimethoxybenzene 
• 140681-55-6 Selectfluor 
• 89-86-1 4-hydroxysalicylic acid 
• 2040-04-2 2,6-dimethoxyacetophenone 
• 699-83-2 2,6-dihydroxylacetophenone 
• 195136-62-0 1-Fluoro-2,4-dimethoxy-5-nitro-benzene 
• 195136-65-3 1-Amino-2,4-dimethoxy-5-fluorobenzene 
• 2105-61-5 1,2,4-trifluoro-5-nitrobenzene 
• 117902-11-1 2,6-dimethoxy-3-fluoroacetophenone 
• 17715-70-7 1,3-dimethoxy-4-fluorobenzene 

Downstream Products

• 404335-93-9 dihydro-fluozin-3, trimethyl ester 
• 178374-98-6 6-fluoro-7-hydroxy-2,3-dihydro-4H-chromen-4-one 
• 952053-73-5 methyl 4-[bis(5-fluoro-2,4-dihydroxyphenyl)methyl]-3-methylbenzoate 
• 869634-72-0 ({4-[bis-(5-fluoro-2,4-dihydroxy-phenyl)methyl](2-methoxyphenyl)}methoxycarbonylmethylamino)acetic acid methyl ester 
• 825628-77-1 1-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester 
• 443302-14-5 C₃₆H₃₀F₂N₂O₁₁S 
• 443302-16-7 C₃₆H₃₀F₂N₂O₁₁S 
• 781666-16-8 3-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-9,10-diphenyl-anthracene-2-carboxylic acid 
• 913689-08-4 2-(2,7-difluoro-3,6-dihydroxy-9H-xanthen-9-yl)benzoic acid 

Relevant articles and documents

Decarboxylative Fluorination of Arylcarboxylic Acids Promoted by ortho-Hydroxy and Amino Groups

A novel decarboxylative fluorination process has been developed for the synthesis of ortho-hydroxy/amino arylfluorides from salicylic acid analogs, in which the ortho-hydroxy/amino group plays an important role in the transformation. In addition, various arylfluorides are obtained in good to excellent yields under mild conditions.

FLUORINATED 4' ALKYLUMBELLIFERYL α-D-GLUCOPYRANOSIDES, BIOLOGICAL STERILIZATION INDICATORS INCLUDING THE SAME AND METHODS OF USING THE SAME

A self-contained biological sterilization indicator comprises: a housing; bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of an enzyme substrate; and a frangible container containing a composition, wherein the composition comprises the enzyme substrate, wherein if the frangible container is broken the composition will contact the bacterial spores to form a mixture having an initial pH in the range from 6.0 to 9.0. The enzyme substrate comprises a fluorinated 4'-alkylumbelliferyl α-D-glucopyranoside represented by the structural formula (I) wherein one of R1 and R2 is F and the other is H, and R3 is an alkyl group having from 1 to 12 carbon atoms. A biological sterilization indicator comprising a kit containing isolated components comprising (i) bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of the enzyme substrate and a method of assessing efficacy of a sterilization process are also disclosed.

Fluorination of aromatic compounds with N-fluorobenzenesulfonimide under solvent-free conditions

Reactions of N-fluorobenzenesulfonimide with methylbenzenes, phenols, and phenol ethers were studied under solvent-free conditions. The rate constant ratio for the reactions with mesitylene and durene indicates polar mechanism of the process. Solvent-free fluorination of aromatic compounds with N-fluorobenzenesulfonimide in some cases is more selective than reactions with other N-F reagents in a solvent.