(S)-1-amino-N-(1-cyano-2-(4'-cyanobiphenyl-4-yl)ethyl)cyclopentanecarboxamide trifluoroacetate

Base Information

Chemical Name:(S)-1-amino-N-(1-cyano-2-(4'-cyanobiphenyl-4-yl)ethyl)cyclopentanecarboxamide trifluoroacetate
CAS No.:1352151-87-1
Molecular Formula:C₂HF₃O₂*C₂₂H₂₂N₄O
Molecular Weight:472.467
Hs Code.:

Synonyms:(S)-1-amino-N-(1-cyano-2-(4'-cyanobiphenyl-4-yl)ethyl)cyclopentanecarboxamide trifluoroacetate

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Chemical Property of (S)-1-amino-N-(1-cyano-2-(4'-cyanobiphenyl-4-yl)ethyl)cyclopentanecarboxamide trifluoroacetate

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Technology Process of (S)-1-amino-N-(1-cyano-2-(4'-cyanobiphenyl-4-yl)ethyl)cyclopentanecarboxamide trifluoroacetate

There total 5 articles about (S)-1-amino-N-(1-cyano-2-(4'-cyanobiphenyl-4-yl)ethyl)cyclopentanecarboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103882-09-3,62129-44-6
N-Boc-4-I-Phe-OH

: 1352151-87-1
(S)-1-amino-N-(1-cyano-2-(4'-cyanobiphenyl-4-yl)ethyl)cyclopentanecarboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 16 h / 0 - 28 °C

2.1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / 1,4-dioxane; water / 18 h / 75 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 48 h / 17 - 28 °C

5.1: Burgess Reagent / dichloromethane / 72 h / 17 - 28 °C

6.1: formic acid / 0.17 h / 50 °C

With N-ethylmorpholine;; formic acid; Burgess Reagent; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 868694-44-4
[(1S)-1-carbamoyl-2-(4-iodophenyl)ethyl]carbamic acid tert-butyl ester

: 1352151-87-1
(S)-1-amino-N-(1-cyano-2-(4'-cyanobiphenyl-4-yl)ethyl)cyclopentanecarboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / 1,4-dioxane; water / 18 h / 75 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 48 h / 17 - 28 °C

4: Burgess Reagent / dichloromethane / 72 h / 17 - 28 °C

5: formic acid / 0.17 h / 50 °C

With formic acid; Burgess Reagent; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1254318-96-1
(S)-tert-butyl (1-amino-3-(4'-cyano-[1,1'-biphenyl]-4-yl)-1-oxopropan-2-yl)carbamate

: 1352151-87-1
(S)-1-amino-N-(1-cyano-2-(4'-cyanobiphenyl-4-yl)ethyl)cyclopentanecarboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 48 h / 17 - 28 °C

3: Burgess Reagent / dichloromethane / 72 h / 17 - 28 °C

4: formic acid / 0.17 h / 50 °C

With formic acid; Burgess Reagent; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;